Robert E. Gross, MD, PhD

    MBNA Bowman Chair & Professor

    Emory University Department of Neurosurgery

    Director and Co-Founder

    Emory Neuromodulation and Technology Innovation Center (ENTICe)

    Director

    Translational Neuro-Engineering Laboratory

    Director

    Stereotactic, Functional Neurosurgery & Epilepsy Surgery

    Education

    • BA, Brown University, 1981
    • MS, Albert Einstein College of Medicine, 1990
    • PhD, Albert Einstein College of Medicine, 1990
    • MD, Albert Einstein College of Medicine, 19980
    • General Surgery Internship, Albert Einstein College of Medicine, 1991
    • Neurological Surgery Residency, Albert Einstein College of Medicine, 1996
    • Functional and Stereotactic Neurosurgery Fellowship, University of Toronto, 1998
    • Epilepsy Surgery Visiting Fellowship, Yale University, 1998

    Biography

    Honors

    • Winter Conference on Brain Research Travel Fellowship, 2000
    • Michael J. Fox Foundation Young Investigator Award, 2000
    • New York Academy of Medicine Charles Elsberg Fellowship in Neurosurgical Research, 2000
    • Neurosurgery Research and Education Foundation of the American Association of Neurological Surgeons Young Clinician Investigator Award, 1999
    • The Toronto Hospital and University of Toronto Botterell Fellowship in Neurosurgery, 1996
    • The Leo M. Davidoff Society Certificate of Distinction, 1996
    • The New York Society for Neurosurgery Elsberg Award for Excellence in Resident Research, 1995
    • Medical Scientist Training Program Scholarship, 1982
    • Brown University Honors in Neural Sciences, 1982
    • Sigma Xi Research Society, 1981

    Clincal Focus

    • Ablative procedures
    • Cell therapy
    • Deep brain stimulation
    • Dystonia
    • Epilepsy
    • Epilepsy surgery
    • Gene therapy
    • Neurodegenerative disorders
    • Parkinson's disease
    • Physiology of movement disorders
    • Restorative approaches
    • Transplantation
    • Tremor

    Society Memberships

    • Biomedical Engineering Society
    • Parkinson’s Study Group (Functional Neurosurgery Committee)
    • Georgia Neurosurgical Society
    • American Society for Neural Transplantation and Repair
    • Movement Disorders Society
    • American Epilepsy Society
    • Utah Medical Association
    • American Society for Stereotactic Functional Neurosurgery
    • Utah Neurosurgical Society
    • American Association of Neurological Surgeons
    • American Medical Association
    • Society for Neuroscience
    • Congress for Neurological Surgeons

    Research

    Research Focus

    (1) Cellular and Gene Therapy for Parkinson’s Disease

    Elucidation of the role of axon guidance molecules in the development and reconstruction of the nigrostriatal pathway, which degenerates in Parkinson’s Disease, and development of gene therapy approaches to improve axon outgrowth for reconstruction. This approach, which encompasses molecular and cellular engineering in combination with neurotransplantation, may be generally useful in reconstructive approaches for many types of nervous system degeneration and injury, including spinal cord injury and stroke.

    (2) Electrical and Optogenetic Neuromodulation and Closed-Loop Feedback of the Brain for Epilepsy

    Development of novel strategies for the treatment of intractable focal epilepsy through the use of microelectrode recording techniques using closed-loop, adaptive algorithms to drive multielectrode microstimulation of brain nuclei involved in seizure modulation. Extension to optogenetic techniques for neuromodulation for epilepsy. Role of neuromodulation for mood and memory disturbance in epilepsy.

    Publications

    • Gutekunst C-A, Gross RE. Plexin A4 Expression in Adult Rat Cranial Nerves. J. Chem. Neuroanat. 2014 Jun 23. pii: S0891-0618(14)00044-1. doi: 10.1016/j.jchemneu.2014.06.003. [Epub ahead of print] PMID: 24970554
    • Desai SA, Gutekunst C-A, Potter SA, Gross RE. Microelectrode vs. macroelectrode deep brain stimulation. Frontiers in Neuroengineering 12 June 2014; doi: 10.3389/fneng.2014.00016
    • Riva-Posse P, Choi K-S, Holtzheimer PE, McIntyre CC, Gross RE, Chaturvedi A, Crowell AL, Garlow SJ, Rajendra JK, Mayberg HS. Defining Critical White Matter Pathways Mediating Successful Subcallosal Cingulate Deep Brain Stimulation for Treatment-Resistant Depression, Biol Psychiatr 2014 Apr 13. pii: S0006-3223(14)00244-3. doi: 10.1016/j.biopsych.2014.03.029. [Epub ahead of print]
    • Willie JT, Laxpati NG, Drane DL, Gowda A, Appin CL, Hao C, Brat DJ, Helmers SL, Saindane AM, Nour SG, Gross RE. Real-Time Magnetic Resonance-Guided Stereotactic Laser Amygdalohippocampotomy for Mesial Temporal Lobe Epilepsy, Neurosurgery 2014 Jun;74(6):569-85. doi: 10.1227/NEU.0000000000000343. (Epub 3/2014 ahead of print).
    • Heck, CN, King-Stephens D, Massey AD, Nair DR, Jobst BC, Barkley GL, Salanova V, Cole AJ, Smith MC, Gwinn RP, Skidmore C, Van Ness PC, Bergey GK, Park YD, Miller I, Geller E, Rutecki PA, Zimmerman R, Spencer DC, Goldman A, Edwards JC, Leiphart JW, Wharen RE, Fessler J, Fountain NB, Worrell GA, Gross RE, Eisenschenk S, Duckrow RB, Hirsch LJ, Bazil C, O'Donovan CA, Sun FT, Courtney TA, Seale CG, Morrell MJ. Two-year seizure reduction in adults with medically intractable partial onset epilepsy treated with responsive neurostimulation: Final results of the RNS System Pivotal trial. Epilepsia 2014 Mar;55(3):432-41. doi: 10.1111/epi.12534. Epub 2014 Feb 22.
    • Wu C, Lariviere MJ, Laxpati N, Evans JJ, Gross RE, Sharan AD. Extraventricular Long-Axis Cannulation of the Hippocampus: Technical Considerations. Neurosurgery. 2014 Jun;10 Suppl 2:325-33. doi: 10.1227/NEU.0000000000000320.
    • Gess JL, Denham M, Pennell PB, Gross RE, Stringer AY. Remediation of a Category-Specific Naming Deficit Following Left Temporal Lobe Epilepsy Surgery. Applied Neuropsychology-Adult. Pub online 12 Sept. 2013; DOI:10.1080/09084282.2013.791826
    • Lujan JL, Chaturvedi A, Choi KS, Holtzheimer PE, Gross RE, Mayberg HS, McIntyre CC. Tractography-activation models applied to subcallosal cingulate deep brain stimulation. Brain Stimul. 2013;6(5):737-9. doi:10.1016/j.brs.2013.03.008. Epub 2013 Apr 6. PubMed PMID: 23602025; PubMed Central PMCID: PMC3772993.
    • James GA, Tripathi S, Ojemann JG, Gross RE, Drane DL. Diminished Default Mode Network Recruitment of Hippocampus and Parahippocampus in Temporal Lobe Epilepsy, J Neurosurg., 2013;119(2):288-300. doi: 10.3171/2013.3.JNS121041. Epub 2013 May 24. PubMed PMID: 23706058.
    • Gu H, Yu SP, Gutekunst C, Gross RE*, Wei L*. Inhibition of the Rho signaling pathway improves neurite outgrowth and neuronal differentiation of mouse neural stem cells. Int J Physiol Pathophysiol Pharmacol, 2013;5(1):11-20. Epub 2013 Mar 8. PubMed PMID: 23525456; PubMed Central PMCID: PMC3601458.. (*co-corresponding authors)

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