Nealen G. Laxpati, MD, PhD

PGY-1

Department of Neurosurgery, Emory University School of Medicine

Education

  • MS, University of Southern California, 2007
  • PhD, Georgia Institute of Technology, 2014
  • MD, Emory University, 2016

Biography

Hometown: Chicago, Illinois

Areas of Interest

  • Functional
  • Epilepsy

Future Plans/Career

  • Academics
  • Private Practice

Awards/Grants

  • Emory MD/PhD Retreat "Best Senior Graduate Poster, 2014
  • Epilepsy Foundation Pre-Doctoral Research Training Fellowship Principal Investigator, 2013-14
  • National Institutes of Health T32 Training Grant Principal Investigator, 2012-13
  • American Epilepsy Society Young Investigator Travel Award, 2012
  • 27th Annual National MD/PhD Student Conference Emory Student Representative, 2012
  • Amercan Society fo Stereotactic and Functional Neurosurgery Biennial Meeting Best Scientific Abstract, 2012
  • American Epilepsy Society Research Initiative Fund Graduate Student Researcher, 2011-12
  • Marine Biolgoical Laboratory Neuroinformatics Course Full Scholarship and Travel Award, 2011

Memberships

  • American Association of Neurological Surgeons
  • Institute for Electrical and Electronics Engineers
  • Society for Neuroscience
  • Tau Beta Pi

Hobbies

  • Water polo 

Research

Dr. Laxpati's research involves cell-type specific optogenetic modulation of septohippocampal circuitry for the treatment of epilepsy in vivo. 

Publications

  • Gross, R.E., Sung, E.K., Mulligan, P., Laxpati, N.G., Hudson, K.A., Lobel, D.A., Rolston, J.D., Accuracy for frameless image-guided implantation of depth electrodes for intracranial epilepsy monitoring. (Submitted).
  • Laxpati, N.G., Mahmoudi, B., Gutekunst, C.A., Newman, J.P., Zeller-Townson, R.T., Gross, R.E., Real-time in vivo optogenetic neuromodulation and multielectrode electrophysiology recording with NeuroRighter. Frontiers in Neuroengineering, 2014 Oct 29; 7:40.
  • Laxpati, N.G.*, Kasoff, W.S.*, Gross, R.E. Deep Brain Stimulation for the Treatment of Epilespy: Circuits, Targets, and Trials. Neurotherapeutics, Invited Review.  2014 Jun 24.
  • Willie, J.T., Laxpati, N.G., Drane, D.L., Gowda, A., Appin, C.L., Hao, C., Brat, D.J., Helmers, S.L., Saindane, A.M., Nour, S.G., Gross, R.E., Real-time magnetic resonance-guided stereotactic laser amygdalohippocampotomy for Mesial Temporal Lobe Epilepsy. Neurosurgery, 2014 Jun;74(6):569-84; discussion 584-5.
  • Wu, C. LaRiviere M.J., Laxpati, N.G., Evans, J.J., Gross, R.E., Sharanya A.D. Extraventricular Long-Axis Cannulation of the Hippocampus: Technical Considerations. Neurosurgery, 2014 Jun;10 Suppl 2:325-32; discussion 332-3. 
  • Laxpati, N.G., Gutekunst, C.A., Gross, R.E. Adapting NeuroRighter for in vivo optogenetic stimulation. Neural Engineering (NER), 2013 6th International IEEE/EMBS Conference on Neuroengineering, vol., no., pp.136,139, 6-8 Nov. 2013
  • Newman, J.P., Fong, M.F.,Laxpati, N.G., Zeller-Townson, R., French, T., Potter, S.M. Optogenetic feedback control decouples network spiking from other forms of neural activity. Conference Proceedings of the 8th International Meeting on Substrate-Integrated Microelectrode Arrays Reutlingen, Germany, pp. 92-93 July 10-13, 2012. 
  • Rolston, J.D., Desai, S.A., Laxpati, N.G., Gross, R.E., Electrical Stimulation for Epilepsy: Experimental Approaches. Neurosurgery Clinics of North America, Invited Review, 2011 Oct;22(4):425-42.
  • Rolston, J.D., Laxpati, N.G., Gutekunst, C. A., Potter, S. M., Gross, R. E. Spontaneous and evoked high-frequency oscillations in the tetanus toxin model of epilepsy. Epilepsia, 2010.
  • Laxpati, N.G. and R.E. Gross, Axons in the Neuropil Are Activated By Electrical Stimulation of the Cortex: Some Surprises, Some Clinical Implications. Neurosurgery, 2010. 66(6).

Abstracts

  • Tung, J., Laxpati, N.G., Gross, R.E. (2014) Optogenetic Inhibition Using a Genetically Encoded Bioluminescent Light Source. American Society for Stereotactic and Functional Neurosurgery Biennial Meeting. May 31-June 3. Washington, D.C.
  • Mahmoudi, B., Desai, S.A., Laxpati, N.G., Gross, R.E. (2013) State representation using subspace projection of CA1-CA3 local field potentials in a rat model of focal epilepsy. American Epilepsy Society 2013 Annual Meeting. December 6-10. Washington, D.C.
  • Tung, J., Gutekunst, C.A., Laxpati, N.G., Wei, L., Gross, R.E. (2013) Optogenetic inhibition using a genetically encoded bioluminescent light source. Society for Neuroscience. Nov 9-13. San Diego, CA.
  • Laxpati, N.G., Chiruvella, M., Tung, J., Gutekunst, C.A., Gross, R.E. (2013) Neuron-type specific optogenetic stimulation of the medial septum for the treatment of epilepsy. American Epilepsy Society 2013 Annual Meeting. December 6-10. Washington, DC.
  • Korb, P., Willie, J.T., Laxpati, N.G., Saindane, A., Nour, S.G., Gowda, A., Gross, R.E. (2013) Real-Time MRI-Guided Stereotactic Laser Thermal Amygdalohippocampectomy (SLTAH) for Refractory Mesial Temporal Lobe Epilepsy. 2013 American Academy of Neurology Annual Meeting. March 16-23. San Diego, CA.
  • Laxpati, N.G., Tung, J., Newman, J., Zeller-Townson, R., Gutekunst, C.A., Gross, R.E. (2012) Optogenetic control of the medial septum drives hippocampal oscillatory activity. Society for Neuroscience 2012 Annual Meeting. October 13-17. New Orleans, LA.
  • Willie, J.T., Laxpati, N.G., Saindane, A., Nour, S.G., Gowda, A., Gross, R.E. (2012) Real-time magnetic resonance-guided stereotactic laser thermal amygdalohippocampotomy (SLTAH) for mesial temporal lobe epilepsy. American Epilepsy Society 2012 Annual Meeting. November 30-December 4. San Diego, CA.
  • Gross, R.E., Laxpati, N.G., Desai, S.A., Tung J., Gutekunst, C.A., Potter S.M. (2012) Electrical and optogenetic neuromodulation of septohippocampal oscillations for the treatment of epilepsy. The American Academy of Neurological Surgery 74th Annual Meeting. October 17-20, Chatham, MA.
  • Willie, J.T., Laxpati, N.G., Saindane, A., Nour, S.G., Gowda, A., Gross, R.E. (2012) Real-Time Magnetic Resonance-Guided Stereotactic Laser Thermal Amygdalohippocampotomy (SLTAH) for Mesial Temporal Lobe Epilepsy. American Society for Stereotactic and Functional Neurosurgery. June 3-6. San Francisco, CA.
  • Laxpati, N.G., Gutekunst, C.A., Gross, R.E. (2011) Optogenetic activation of hippocampal pyramidal cells is dependent upon parameters of stimulation. Society for Neuroscience. November 12-16. Washington, DC.