Publications

Boulis NM and Mader BM (in press). Chapter 9: Viral Vectors and other Modulatory Biologics. Innovative Neuromodulation. Elsevier.

McEachin ZT, Donsante A, Boulis NM (in press).  Gene Therapy for the Treatment of Neurological Disorders: Amyotrophic Lateral Sclerosis.  In Fredric P. Manfredsson (Ed.), Methods in Molecular Biology.  New York, New York:  Springer.

Donsante A, Urquia L, Boulis NM (in press).  Stem Cells for Amyotrophic Lateral Sclerosis.  In Mark H. Tuszynski (Ed.), Translational Neuroscience.  New York, New York:  Springer.

Gutierrez J, Lamanna JJ, Grin N, Hurtig CV, Miller JH, Riley J, Urquia L, Avalos P, Svendsen CN, Federici T, Boulis NM. Preclinical Validation of Multilevel Intraparenchymal  Stem Cell Therapy in the Porcine Spinal Cord.  Neurosurgery. 2015 Jul 1. PMID:26134596

O'Connor, DM and Boulis, NM. Gene Therapy for Neurodegenerative Diseases. Trends in Molecular Medicine (2015) 21: 504-512, 2015.

Shaikh AG, Mewes K, DeLong MR, Triche SD, Jinnah HA, Gross RE, Boulis N, Freeman A, Alexander GE, Aia P, Butefisch CM, Esper CD, Factor SA. Temporal profile of improvement of tardive dystonia after globus pallidus DBS. Parkinsonism and Related Disorders. 21 (2): 116-119, 2015.

Tadesse T, Gearing M, Senitzer D, Saxe D, Brat D, Bray R, Gebel H, Boulis NM, Riley J, Feldman E, Johe K, Hazel T, Polak M, Bordeau J, Buchman T, Glass JD.  Analysis of graft survival in a trial of stem cell transplant in ALS. Annals of Clinical and Translational Neurology. 1: 900–908, 2014.

Davis AS, Federici T, Bouls NM, Ray WC, O’Connor DM, Clark KR, and Bartlett JS. Rational design and engineering of a modified AAV1-based vector system for enhanced retrograde gene delivery.  Neurosurgery,  76:216–225, (2015).

Messenger SW, Falkowski MA, Thomas DDH, Jones EK, Hong W, Giasano HY, Boulis NM, Groblewski GE.  VAMP8 mediated zymogen granule exocytosis is dependent on endosomal trafficking via the constitutive-like secretory pathway. J of Biological Chemistry 289(40): 28040-53 (2014).

Sharma M, Rhiew R, Deogaonkar M, Rezai A, Boulis NM. Accuracy and Precision of Targeting Using Frameless Stereotactic System in Deep Brain Stimulator Implantation Surgery. Neurology India 62(5): 503-9, 2014.

Keifer O, Riley J, Boulis N. Deep Brain Stimulation for Chronic Pain:  Intracranial Targets, Clinical Outcomes, and Trial Design Considerations.  Neurosurgery Clinics of North America.  2014.  25(4)671-692.  PMID 25240656

Gutierrez J, Raju S, Riley J, Boulis N. Introduction to Neuropathic Pain Syndromes. Neurosurgery Clinics of North America.  2014 Oct;25(4):639-662. PMID  25240654

Bethoux F, Boulis N, McClelland III S, Willis MA, Hussain M, Machado A, Mychkovsky L, Stough D, Sutliff M, Pioro EP. Use of intrathecal baclofen for treatment of severe spasticity in selected patients with motor neuron disease. Neurorehabilitation and Neural Repair 27(9): 828-33 (2013).

Feldman EL, Boulis NM, Hur J, Hazel TG, Johe K, Rutkove SB, Federici T, Polak M, Bordeau J, Sakowski SA, Glass JD. Intraspinal Neural Stem Cell Injections in ALS Patients: Phase I Trial Outcomes. Annals of Neurology, 75(3): 363-73, 2014.

Passini MA, Bu J, Richards AR, Treleaven CM, Sullivan JA, O'Riordan CR, Scaria A, Kells AP, Samaranch L, San Sebastian W, Federici T, Fiandaca MS, Boulis NM, Bankiewicz K, Shihabuddin LS, Cheng SH. Translational Fidelity of Intrathecal Delivery of scAAV9-SMN1 for Spinal Muscular Atrophy. Hum Gene Ther. 2014 Mar 11. [Epub ahead of print].

Lamanna JL, Miller JH, Riley JP, Hurtig VP, Boulis NM. Cellular therapeutics delivery to the spinal cord: technical considerations for clinical application. Ther. Deliv. 4(11), 1397–1410 (2013).

Riley J, Federici T, Polak M, Kelly C, Glass J, Feldman E, Boulis N.  Intraspinal Stem Cell Transplantation in ALS: A Phase I Trial, Cervical Microinjection and Final Surgical Safety Outcomes.  Neurosurgery.  74(1)77-87.  PMID: 24018694

Simonato M, Bennett J, Boulis NM, Castro MG, Fink DJ, Goins WF, Gray SJ, Lowenstein PR, Vandenberghe LK, Wilson TJ, Wolfe JH, Glorioso JC.  Progress in gene therapy for neurological disorders. Nat Rev Neurol. 2013 May; 9(5): 277-91.  

Bartus RT, Baumann TL, Siffert J, Herzog CD, Alteman R, Boulis NM, Turner D, Stacey M, Lang AE, Lozano AM, Olanow CW. Safety/feasibility of targeting the substantia nigra with AAV2-neurturin in Parkinson patients. Neurology. 2013 Apr 30; 80(18): 1698-701.

Boulis NM, Krudy CA, Handy CR, Donnelly EM, Federici T, Franz CK, Barrow EM, Teng Q, Kumar P, Cress D.  (2013)  Regulated neuronal neuromodulation via spinal cord expression of the gene for the inwardly rectifying potassium channel 2.1 (Kir2.1).  Neurosurgery 72(4): 653-661.

Federici T, Hurtig CV, Burks KL, Riley JP, Krishna V, Miller BA, Sribnick EA, Boulis NM.  (2012) Surgical Technique for Spinal Cord Delivery of Therapies-Demonstration of Procedure in Gottingen Minipigs. Journal of Visualized Experiments, (), e4371.

O’Connor D and Boulis NM.  (2012) Cellular and Molecular Approaches to motor neuron therapy in Amyotrophic Lateral Sclerosis and Spinal Muscular Atrophy. Neuroscience Letters 527(2): 78-84.

Glass JD, Boulis NM, Johe K, Rutkove SB, Federici T, Polak M, Kelly C, Feldman EL. (2012) Lumbar intraspinal injection of neural stem cells in patients with ALS: results of a Phase I trial in 12 patients. Stem Cells. 30(6): 1144-51.

Riley J, Federici T, Polak M, Kelly C, Glass JD, Feldman EL, Boulis NM.  (2012)  Intraspinal stem cell transplantation in ALS; A Phase I Safety Trial, Technical Note and Lumbar surgical safety.  Neurosurgery 71(2): 405-416.

Sribnick EA and Boulis NM. (2011) Treatment of Harlequin Syndrome by costotransversetomy and sympathectomy: Case Report.  Neurosurgery 69(1): E257-259.

Federici T, Boulis NM. (2012)  Gene therapy for amyotrophic lateral sclerosis. Neurobiol Dis. 48; 236-242.

Donnelly EM, Quach ET, Hillary TM, Heeke BL, Snyder BR, Handy CR, O’Connor DM, Boulis NM, Federici T. (2012) Characterization of a Murine Model of SMA. Neurobiol Dis. 45(3):992-8.  

Boulis NM, Federici T, Glass JD, Lunn JS, Sakowski SA, Feldman EL.  (2011)  Translational Stem Cell Therapy for Amyotrophic Lateral Sclerosis. Nature Reviews Neurology 8(3): 172-6.

Federici T, Taub JS, Baum GR, Gray SJ, Grieger JC, Matthews KA, Samulski RJ, and Boulis NM (2012).  Robust spinal motor neuron transduction following intrathecal delivery of AAV9 in pigs. Gene Therapy, 19(8):852-9.  15 Advanced online publication September 2011, 1-8. doi: 10.1038/gt.2011.130

Handy CR, Krudy CA, Boulis NM. Gene Therapy: A Potential Approach for Cancer Pain. (2011) Pain Res and Treatment: 987597.

Kliem MA, Heeke B, Franz CK, Radovitskiy I, Raore B, Barrow E, Snyder BR, Federici T, Spratt K, and Boulis NM (2011). Intramuscular administration of a VEGF Zinc Finger Transcription Factor Activator (VEGF-ZFP-TF) improves outcomes in SOD1 rats. Amyotrophic Lateral Sclerosis 12(5): 331-9.

Snyder BR, Gray SJ, Quach ET, Huang JW, Leung CH, Samulski RJ, Boulis NM, and Federici T (2011). Comparison of Adeno-Associated Viral Vector Serotypes for Spinal Cord and Motor Neuron Gene Delivery. Human Gene Therapy, 22(9): 1129-35.

Leung CH, Kliem MA, Heeke BL, McPhee SW, Federici T, Snyder BR, and Boulis NM (2011). Assessment of Hippocampal Adeno-Associated Viral Vector Gene Delivery via Frameless Stereotaxis in a Nonhuman Primate. Stereotactic Functional Neurosurgery, 89: 275-285.

Riley JP, Raore B, Taub JS, Federici T, and Boulis NM (2011). Platform and Cannula Design Improvements for Spinal Cord Therapeutics Delivery. Neurosurgery Suppl 2: 147-155.

Amadio J and Boulis NM (2011). Bioethical Aspects of Treating Parkinsonian Patients with Subthalamic Nucleus Neuromodulation. American Journal of Bioethics Neuroscience, 2(1): 24-26, 2011.

Marks WJ, Bartus RT, Siffert J, Davis CS, Lozano A, Boulis NM, Vitek J, Stacy M, Turner D, Verhagen L, Bakay R, Watts R, Guthrie B, Jankovic J, Simpson R, Tagliati M, Alterman R, Stern M, Baltuch G, Starr PA, Larson PS, Ostrem JL, Nutt J, Kieburtz K, Kordower J, and Olanow CW (2011).  Double-Blind, controlled trial of gene delivery of AAV2-Neurturin for Parkinson’s Disease. Lancet Neurology 9(12); 1164-72.

Lastfogel JF, Bendok BR, Boulis NM, and Cohen-Gadol AA (2011). Clinical Problem Solving; Aneurysm or Spinal Arteriovenous fistula-bait and switch. Neurosurgery 68(3); E866-73.

Muh CR, Boulis NM, Chandler WF, Barkan AL, and Oyesiku NM (2011). Clinical Problem Solving; Monster on the Hook. Neurosurgery 68(3): E874-82.

Raore B, Federici T, Taub J, Wu MC, Riley J, Franz CK, Kliem MA, Snyder B, Feldman EL, Johe K, and Boulis NM (2011). Cervical Multilevel Intraspinal Stem Cell Therapy: Assessment of Surgical Risks in Gottingen Minipigs. Spine, 36(3), 164-171.

Lunn JS, Sakowski SA, Federici T, Glass JD, Boulis NM, and Feldman EL (2011). Stem cell technology for the study and therapeutic intervention of motor neuron diseases. Regenerative Medicine, 6(2) 201-213.

Natarajan SK, Siddiqui AH, Hopkins N, Boulis NM, & Levy EI (2010).  To glue or not to glue? That is the question!!!  Neurosurgery, 67(4), 1181-1188.

Hadjipanayis CG, Schuette AJ, Boulis NM, Hao C, Barrow DB, & Theo C (2010). Full scope of options.  Neurosurgery, 67(1), 197-204.

Snyder B, Boulis NM, Federici T. (2010) Viral Vector-Mediated Gene Transfer for CNS disease. Expert Opinion on Biological Therapy 10(3): 381-94.

Connolly ES, Hoh BL, Selden NR, Asher AL, Kondziolka D, Boulis NM, Barker FG.  (2009) Clipping versus coiling for ruptured intracranial aneurysms: Interactive Medical Learning at CNS 2007, Part 4.  Neurosurgery, 66(1): 19-34.

Vogelbaum MA, Asher AL, Kondziolka D, Boulis NM, Selden NR, Hoh BL, Barker FG 2nd. (2009) Modern treatment of cerebral metastases: Interactive Medical Learning at CNS 2007.  J Neuro-Oncology 93(1); 89-105.

Riley J, Svendsen C, Federici T, Park J, Suzuki M, Teng Q, Boulis NM (2009). Safety of cervical spinal cord cell transplant in the farm pig using a spine immobilized platform designed for human application.  Neurosurgery 65 (4): 754-762.

Franz CK, Quach ET, Krudy CA, Federici T, Kleim M, Snyder BR, Raore B, & Boulis NM (2009).  A conditioning lesion provides selective protection in a rat model of amyotrophic lateral sclerosis.  PLoS ONE 4(10): e7357.

Federici T & Boulis NM (2009). Peripheral nervous system as a conduit for delivering therapies for diabetic neuropathy, ALS, and nerve regeneration.  Neurosurgery, 65(4): Suppl: A87-A92.

Henderson JM, Federici T, Boulis NM.  (2009) Optogenetic neuromodulation.  Neurosurgery 64(5): 796-804.

Bragg TM, Scianna J, Kassam A, Emami B, Brown HG, Hacein-Bey L, Clark JI, Muzaffar K, Boulis NM, Prabhu VC.  Clinicopathological Review: Esthesioneuroblastoma. Neurosurgery 64(4): 764-770.

Franz C, Federici T, Yang J, Backus C, Teng Q, Bishop K, Bartus R, Feldman EL, Boulis NM.  (2009) Intraspinal cord delivery of IGF-I mediated by adeno-associated virus 2 is neuroprotective in a rat model of familial ALS.  Neurobiology of Disease 33(3): 473-481.

Federici T, Riley J, Park J, Bain M, Boulis NM. (2009) Preclinical safety and validation of a stabilized viral vector direct injection approach to the cervical spinal cord.  Clinical and Translational Science 2 (2): 165-7.

Federici T, Kutner R, Tordo N, Garrity-Moses M, Boulis NM, Reiser J. (2009) Comparative analysis of HIV-1-based lentiviral vectors bearing lyssavirus glycoproteins for neuronal gene transfer.  Genetic Vaccines and Therapy 7: 1

Carlton E, Teng Q, Federici T, Yang J, Riley J, Boulis NM.  (2008) Retrograde axonal transport and neuroprotection of a fusion protein containing the tetanus toxin C fragment binding domain and Bcl-xL.  Neurosurgery 63(6): 1175-1184.

Spiotta AM, Bain MA, Deogaonkar M, Hammert W, Boulis NM, Rezai A.  (2008) Methods of scalp revision for deep brain stimulator hardware; the Good, the Bad, and the Ugly. Neurosurgery 62(3 Supp 1): 249-50.

Ranalli NJ, Zager EL, McGarvey M, Boulis NM, Kline DG.  (2008) Clinical Problem Solving:  Brachial Plexus Closed Injury and Reconstruction.  Neurosurgery,62(6): 1330-9.

Toms S, Weil RJ, Prayson R, Boulis NM, Lang F. (2008)  Clinical Problem Solving, Island Intruder. Neurosurgery 62(4): 920-927.

Lopez-Gonzalez M, Riley J, Boulis NM, Burchiel K.  (2008) Clinical Problem Solving; Lightning Strikes. Neurosurgery, 62(3): 724-734.

Ugokwe K, Chahlavi A, Bingaman W, Gupta A, Prayson R, Boulis NM, Montes J.  (2008) Clinical Problem Solving;  Seize the Day.  Neurosurgery 62:481-488.

Rezai A, Machado A, Deogaonkar M, Azmi H, Kubu C, and Boulis NM.  (2008) Surgery for Movement Disorders.  Neurosurgery 62(2): Supp809-839. in Surgery of the Human Cerebrum.

Khatib R, Ebrahim Z, Rezai A, Boulis NM, Doyle DJ, Schurigyn T, Farag E.  (2008) Perioperative events during deep brain stimulation: The experience at the Cleveland Clinic. Anesthesia and Analgesia, 20(1): 36-40.

Trayner J, Nesbit G, Scott RM, Boulis NM, Selden NR. (2008) Clinical Problem Solving; Family Matters. Neurosurgery 62:195-201.

McClelland S III, Bethoux FA, Boulis NM, Sutliff MH, Stough DK, Schwetz KM, Gogol DM, Harrison M, Pioro EP (2008). Intrathecal baclofen for spasticity-related pain in ALS: Efficacy and factors associated with pain relief.  Muscle and Nerve, 37(3): 396-398.

Riley J, Butler J, Baker KB, McClelland S III, Teng Q, Yang J, Garrity-Moses M, Federici T, Boulis NM. (2008) Targeted spinal cord therapeutics delivery: stabilized platform and MER guidance validation.  Stereotactic and Functional Neurosurgery 86: 67-74.

Yang J, Qingshan T, Garrity-Moses ME, Federici T, McClelland S III, Boulis NM.  (2007) Hemiparkinsonism induced through unilateral expression of adenovirus-mediated clostridial light chain gene in the substantia nigra.  Neuromolecular Medicine, 9(3): 276-84.

Deogaonkar M, Walter B, Boulis NM, Starr P.  (2007)  Clinical Problem Solving; Find the target. Neurosurgery 61(4): 815-825.

Lotto M and Boulis NM.  (2007) Intrathecal opioids for control of chronic low back pain during deep brain stimulation procedures.  Anesthesia and Analgesia 105: 1410-1412.

Federici T and Boulis NM.  (2007) Gene therapy for peripheral nervous system diseases.  Current Gene Therapy, 7: 239-248.

Ford PJ, Boulis NM, Montgomery EB, Rezai AR. (2007) A patient revoking consent during awake craniotomy; An ethical challenge.  Neuromodulation 10(4): 259-262.

Steinmetz MP, Krishnaney A, Boulis NM, Benzel EC. (2007) Clinical Problem Solving; An invasion of the Atlas.  Neurosurgery 60(6): 1083-7.

Federici T, Liu JK, Teng Q, Yang J, Boulis NM.  (2007) Tet1, a  means for targeting therapeutics to peripheral nervous system neurons with axon damage.  Neurosurgery 60(5): 911-918.

McClelland S III, Teng Q, Benson LS, Boulis NM. (2007)  Motor neuron inhibition-based gene therapy for spasticity.  American Journal of Physical Medicine and Rehabilitation, 86(5): 412-421.

Yang J, Teng Q, Garrity-Moses M, Federici T, Najm I, Chabardes S, Moffitt M, Boulis NM.  (2007) Gene therapy of epilepsy by adenovirus-mediated tetanus toxin light chain gene transfer.  Mol Therapy 15(3): 542-551.

Federici T and Boulis NM.  (2006) RNA interference for neurological disorders:  candidate diseases, potential targets, and current approaches.  Neurosurgery 60(1): 3-16.

Federici T, Teng Q, Yang J, Garrity-Moses M, Boulis NM.  (2006) Neuronal affinity of a C7C loop peptide identified through phage display.  Journal of Drug Targeting, 14(5):263-71.

Garrity-Moses M, Teng Q, Krudy C, Yang J, Federici T, Boulis NM. (2006)  XIAP Gene-based Neuroprotection for the Peripheral Nervous System.  Neurosurgery 59(1): 172-182.

Zhao Z, Krishnaney A, Teng Q, Garrity-Moses M, Liu JK, Venkiteswaran K, Subramanian T, Davis M, Boulis NM. (2006) Anatomically discrete functional effects of adenoviral clostridial light chain gene-based synaptic inhibition in the deep layers of the superior colliculus/deep mesencephalic nucleus of the midbrain.  Gene Therapy, 13; 942-952.

Federici, T and Boulis, NM.  (2006) Gene-based treatment of motor neuron disease.  Muscle and Nerve 33(3): 302-323.

Salazar F, Machado A, Stevens G, Murthy S, Boulis NM. (2005) Thoracoscopically Guided Transaxillary Resection of Adjoining Intercostal Plexiform Neurofibromas; Review of Mosaicism in Neurofibromatosis.  Neurosurgery 57(4)(Operative Neurosurgery Supp 4): E407.

Pilitsis JG, Rezai AR, Boulis NM, Hendersen JM, Busch RM, Kubu CS. (2005) A preliminary study of transient confusional states following bilateral subthalamic stimulation for Parkinson’s disease.  Stereotactic and Functional Neurosurgery 83(2-3): 67-70.

Teng, Q, Garrity-Moses M, Tanase D, Liu JK, Mazarakis N, Azzouz M, Walmsley L, Carlton E, Boulis NM.  (2005) Trophic activity of rabies G protein pseudotyped equine infectious anemia viral vector mediated IGF-I motor neuron gene transfer in vitro.  Neurobiology of Disease 20(3): 694-700.

Garrity-Moses M, Teng Q, Liu J,  Tanase D, Boulis NM. (2005) Neuroprotective adeno-associated virus Bcl-xL gene transfer in models of motor neuron disease.  Muscle and Nerve 32(6): 734-744.

Liu J,Teng Q, Garrity-Moses M, Tanase D, Imperiale M, Boulis NM. (2005) A Novel Peptide Defined Through Phage Display for Therapeutic Protein and Vector Neuronal Targeting. Neurobiology of Disease 19(3): 407-418.

Schuele SU, Kellinghaus C, Shook S, Boulis NM, Bethoux FA, Loddenkemper T. (2005) Incidence of seizures in multiple sclerosis patients on intrathecal baclofen. Neurology, 64: 1086-1087.

Vincent A, Feldman E, Song D, Jung V, Schild A, Zhang W, Imperiale M, Boulis NM.  (2004) Adeno-associated Viral-mediated Insulin-like Growth Factor Delivery Protects Motor Neurons In Vitro. NeuroMolecular Medicine 6(2/3): 79-85.

Teng Q, Tanase D, Liu J, Garrity-Moses M, Boulis NM.  (2005) Adenoviral Tetanus Toxin Light Chain Gene-Based Synaptic Inhibition through Neuronal Synaptobrevin Elimination. Gene Therapy 12(2) 108-119.