Professor, Department of Neurosurgery and Winship Cancer Institute Director, Laboratory for Molecular Neuro-Oncology and Brain Tumor Program Emory University School of Medicine 1365C Clifton Rd, NE, room C5078 Atlanta GA 30322 Appt. Phone: 404-778-4358

• Refereed Journals
• Review Articles
• Symposium Contributions
• Book Chapters
• Media Relations
• Research

Erwin G. Van Meir, PhD is a Professor of Neurosurgery and Hematology/ Oncology at the Emory University School of Medicine and Director of the Winship Cancer Institute's Brain Tumor Program and Laboratory of Molecular Neuro-Oncology. Dr Van Meir has extensive experience in cancer research. He was trained in molecular biology at the Universities of Fribourg and Lausanne, Switzerland where he obtained his PhD in 1989. He pursued postdoctoral work at the Ludwig Institute for Cancer Research in San Diego where he uncovered the role of p53 in the negative regulation of glioma angiogenesis, thus extending our conception of p53 as an intrinsic cellular regulator to one with more global control over the cellular environment. He joined the Faculty of Emory University in Atlanta, in 1998.

Dr Van Meir and his colleagues have made several original contributions to cancer research. His research is mainly directed at defining the genetic alterations in brain tumors, determining their biological significance for tumor development, with particular emphasis on angiogenesis and hypoxia, and translating this knowledge into new therapeutic approaches. These advances showed that loss of p53 tumor suppressor function contributes to the early stages of astrocytoma formation in humans.

Contributions in the field of tumor angiogenesis include the demonstration that hypoxia can both increase the production of pro-angiogenic factors as well as reduce the production of inhibitors of angiogenesis and tumor growth, as well as the discovery of Vasculostatin, a fragment of Brain Angiogenesis Inhibitor 1 with a unique angiostatic and tumor prevention role in the brain.

Dr Van Meir's group recently proposed a novel mechanism to explain the development of hypoxia in malignant brain tumors based on vaso-occlusive and regression events; mechanisms that are relevant to angiogenesis and more aggressive tumor growth. His recent research efforts are focused on the development of novel therapies to treat hypoxic tumor cells. These efforts have led to the development of a novel oncolytic adenovirus that targets hypoxic cells, as well as the development of novel small molecules interfering with the Hypoxia-Inducible Factor (HIF) pathway.

Dr Van Meir is an active member of the International Neuro-Oncology community. He currently serves on the Board of Directors of the Society for Neuro-Oncology and the Scientific Advisory Board of the Southeastern Brain Tumor Foundation, has served on the Scientific Committee of the European Association for Neuro-Oncology and has organized several international conferences on brain tumors. He is a member of several international cancer societies and serves on the Editorial Board or as a reviewer for over 30 international scientific journals and reviews scientific proposals for public and private agencies including the US National Institutes of Health (NIH), the US Department of Defense, the Swiss National Science Foundation (SNSF), the Swiss Cancer Society, the Wellcome Trust of the UK, the Research Grants Council of Hong Kong, the Israel Science Foundation and the Italian Association for Cancer Research. His research, supported by the NIH, the SNSF and many private foundations is described in more than 100 peer-reviewed international scientific publications that have cumulated over 3000 citations. He is also the author of several US and foreign patents. These contributions were presented in over 100 invited seminars worldwide and have furthered the understanding of brain tumor biology and genetics as well as led to the development novel preclinical therapeutic approaches.


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Refereed Journals

Back, E., Van Meir, E.G., Müller, F., Schaller, D., Neuhaus, H., Aeby, P. and Tobler, H. (1984). Intervening sequences in the ribosomal RNA genes of Ascaris lumbricoides: DNA sequences at junctions and genomic organization. EMBO J., 3, 2523-2529.

Bertholet, C., Stocco, P., Van Meir, E.G., and Wittek, R., (1986). Functional analysis of the 5' flanking sequence of a vaccinia virus late gene. EMBO J., 5, 1951-1957.

Bertholet, C., Van Meir, E.G. , ten Heggeler-Bordier, B. and Wittek, R. (1987). Vaccinia virus produces late mRNAs by discontinuous synthesis. Cell 50, 153-162.

Van Meir, E.G., and Wittek, R. (1988). Fine structure of the Vaccinia virus gene encoding the precursor of the major core protein 4a. Arch. Virol., 102, 19-27.

Kuppner, M.C., Van Meir, E.G., Hamou, M-F. and de Tribolet, N. (1990). Cytokine regulation of Intercellular Adhesion Molecule-1 (ICAM-l) expression on human glioblastoma cells. Clin. Exp. Immunol., 81, 142-148.

Van Meir, E.G., Sawamura, Y., Diserens, A-C., Hamou, M-F. and de Tribolet N. (1990). Human glioblastoma cells release Interleukin-6 in vivo and in vitro. Cancer Res. 50, 6683-6688.

Beck-Sickinger, A.G., Grouzmann, B., Hoffmann, B., Gaida, W., Van Meir, E.G., Waeber, B. and Jung G. (1992). A novel cyclic analog of neuropeptide Y specific for the Y2-receptor. Eur. J. Biochem., 206 , 957-964.

Frei, K., Piani, D., Malipiero, U.V., Van Meir, E.G., de Tribolet, N. and Fontana, A. (1992). Granulocyte-macrophage colony-stimulating factor (GM-CSF) production by glioblastoma cells: despite the presence of inducing signals GM-CSF is not expressed in vivo. J. Immunol., 1480, 3140-3146.

Van Meir, E.G., Ceska, M., Effenberger, K., Walz, A., Grouzmann, B., Desbaillets, I. Frei, K., Fontana, A. and de Tribolet, N. (1992). lnterleukin-8 is produced in Neoplastic and Infectious Diseases of the Human Central Nervous System. Cancer Res., 52, 4297-4305.

Kuppner, M.C., Van Meir, E.G., Gauthier, Th., Hamou, M-F. and de Tribolet, N. (1992). Differential expression of the CD44 molecule in human brain tumors. Int. J. Cancer., 50, 572-577.

Li, H., Hamou, M-F., de Tribolet, N., Jaufeerally, R., Hofmann, M., Diserens, A-C.and Van Meir, E.G. (1993). Variant CD44 adhesion molecules are expressed in human brain metastases but not in glioblastomas. Cancer Res., 53, 5345-5349.

Tada, M., Sawamura, Y., Sakuma, S., Abe, H., Suzuki, K., Yamakawa, Y., Van Meir, E.G. and de Tribolet, N. (1993). Human glioblastoma cells produce 77-amino acid interleukin-8 (IL-8 77). J. Neuro-Oncol., 16, 25-34.

Takaichi, K., Balkovetz, D.F., Van Meir, E.G. and Warnock, D.G. (1993). Cytosolic pH sensitivity of an expressed human NHE-1 Na+/H+ exchanger. Am. J. Physiol., 264 (Cell Physiol., 33), C944-C950.

Kikuchi, T., Rempel, S., Rutz, H-P., de Tribolet, N., Mulligan, L., Cavenee, W.K., Jothy, S., Leduy, L. and Van Meir, E.G. (1993). Turcot's syndrome of glioma and polyposis occurs in the absence of germline mutations in exons 5 to 9 of the p53 gene. Cancer Res., 53, 957-961.

Liu, J., Li, H., de Tribolet, N., Jaufeerally, R., Hamou, M-F. and Van Meir, E.G. (1994). IL-6 stimulates growth and inhibits constitutive, protein synthesis-independent apoptosis of murine B-cell hybridoma 7TD1. Cell. Immunol., 155, 428-435.

Desbaillets, I., Tada, M., de Tribolet, N, Diserens, A-C., Hamou, M-F. and Van Meir, E.G. (1994). Human astrocytomas and glioblastomas express Monocyte Chemoattractant Protein-1 (MCP-1) in vivo and in vitro. Int. J. Cancer, 58, 240-247.

Kikuchi, T., Diserens, A-C., Hamou, M-F., de Tribolet, N. and Van Meir, E.G. (1994). Overexpression of p53 protein in gliomas. No Shinkei Geka,. 22, 125-129.

Van Meir, E.G., Kikuchi, T., Tada, M., Li, H., Diserens, A-C. , Wojcik, B., Huang, H-J.S., Friedmann, T., de Tribolet, N., and Cavenee W.K. (1994). Analysis of the p53 gene and its expression in human glioblastoma cells. Cancer Res., 54, 649-652.

Van Meir, E.G., Polverini P.G., Chazin, V.R., Huang, H-J.S., de Tribolet, N. and Cavenee, W.K., (1994). Release of an inhibitor of angiogenesis upon induction of wild type p53 expression in glioblastoma cells. Nature Genet., 8, 171-176.

Van Meir, E.G., Roemer, K., Diserens, A-C., Kikuchi, T., Rempel, S.A., Haas, M., Huang H.J.S., Friedmann, T., de Tribolet, N. and Cavenee W.K. (1995). Single-cell monitoring of growth arrest and morphological changes induced by transfer of wild type p53 alleles to glioblastoma cells. Proc. Natl. Acad. Sci. USA., 92, 1008-1012.

Flaman, J-M., Frebourg, T., Moreau, V., Charbonnier, F., Martin, C., Chappuis, P., Sappino, A-P., Limacher, J-M., Bron, L., Benhattar, J., Tada, M., Van Meir, E.G., Estreicher, A. and Iggo, R. (1995). A simple p53 functional assay for screening cell lines, blood and tumors. Proc. Natl. Acad. Sci., USA, 92, 3963-3967.

Van Meir, E.G. (1997). Identification of nude mice in tumorigenicity assays. Int. J. Cancer, 71, 310.

Saas, P., Walker, P.R., Hahne, M., Quiquerez, A-L., Schnuringer, V., Perrin, G., French, L., Van Meir, E.G., de Tribolet, N., Tschopp, J. and Dietrich, P-Y. (1997). Fas ligand expression by astrocytoma in vivo: maintaining immune privilege in the brain? J. Clin. Invest. 99, 1173-1178.

Gratas, C., Tohma, Y., Van Meir, E.G., Tenan, M., Ishii, N., Klein, M., Tachibana, 0., Yonekawa, Y., Kleihues, P., and Ohgaki, H. (1997). Fas ligand expression in glioblastoma cell lines and primary astrocytic brain tumors. Brain Pathol., 7, 863-869.

Tohma, Y., Gratas, C., Van Meir, E.G., Desbaillets, I., Tenan, M., Tachibana, 0., Yonekawa, Y., Kleihues, P., and Ohgaki, H. (1998). Necrogenesis and Fas/APO-1 (CD95) expression in primary and secondary glioblastoma. J. Neuropath. Exp. Neurol. 57, 239-245

Desbaillets, I., Diserens, A-C., de Tribolet, N., Hamou, M-F. and Van Meir, E.G. (1997). Upregulation of IL-8 by oxygen-deprived cells in glioblastoma suggests a role in leukocyte activation, chemotaxis and angiogenesis. J. Exp. Med., 186, 1201-1212.

Maier, D., Comparone, D., Taylor, E., Zhang, Z., Gratzl, 0., Van Meir, E.G., Scott, R.J., and Merlo, A. (1997). New deletion in low grade oligodendroglioma at the glioblastoma suppressor locus on chromosome 10q25-26. Oncogene 15, 997-1000.

Maier, D., Zhang, Z., Taylor, E., Hamou, M-F., Gratzl, 0., Van Meir, E.G., Scott, R. and Merlo, A. (1998). Somatic deletion mapping on chromosome 10 and sequence analysis of PTEN/MMAC1 point to the 10q25-26 region as the primary target in low grade and high grade gliomas. Oncogene 16, 3331-3335

Albertoni, M., Daub, D., Viars, C., Arden, K. and Van Meir, E.G. (1998). Genetic instability leads to loss of both p53 alleles in a human glioblastoma. Oncogene 16, 321-326.

Ishii, N., Sawamura, Y., Tada, M., Daub, D.M., Iggo, R., Meagher-Villemure, K, Janzer, R., de Tribolet, N. and Van Meir, E.G. (1998). Absence of p53 mutations in a tumor panel representative of human pilocytic astrocytoma diversity. Int. J. Cancer 76, 797-800

Weller, M., Rieger, J., Grimmel, C., Van Meir, E.G., de Tribolet, N., Krajewsky, S., Reed, J.C., Von Deimling, A. and Dichgans, J. (1998). Predicting chemoresistance in human malignant glioma cells: the role of molecular genetic analyses. Int. J. Cancer (Pred. Oncol.) 79, 640-644

Ikeda, J., Sawamura, Y., and Van Meir, E.G. (1998). Pineoblastoma presenting in familial adenomatous polyposis (FAP): random association, FAP variant or Turcot syndrome? Br. J. Neurosurg. 12, 576-8.

Gilbert, B., Redondo, J., Baudat, P-A., Lorusso, G.F., Andres, R., Van Meir, E.G., Brunet, J-F., Hamou, MF., Suda, T., Delio Mercanti, Teresa Ciotti, M., Droubay, T.C., Tonner, B.P., Perfetti, P. Margaritondo, G. and De Stasio, G. (1998).Spectromicroscopy of boron for the optimization of Boron Neutron Capture Therapy (BNCT) for cancer. J. Phys. D: Appl. Phys. 31, 2642-2647

Desbaillets, I., Diserens, A-C., de Tribolet, N., Hamou, M-F. and Van Meir, E.G. (1999). Regulation of interleukin-8 expression by reduced oxygen pressure in human glioblastoma. Oncogene 18, 1447-1456

Ishii, N., Maier, D., Merlo, A., Tada, M., Sawamura, Y., Diserens, A-C. and Van Meir EG (1999). Frequent co-alterations of TP53, CDKN2A, p14ARF and PTEN tumor suppressor genes in human glioma cell lines. Brain Pathol. 9, 469-479

Ishii, N., Tada, M., Hamou, M-F., Janzer, R.C., Meagher-Villemure, K., Wiestler, O.D., de Tribolet, N., and Van Meir, E.G. (1999). Cells with TP53 mutations in low grade astrocytic tumors evolve clonally to malignancy and are an unfavorable prognostic factor. Oncogene 18, 5870-5878

Maier, D., Jones, G., Li, X, Schönthal, A., Gratzl, O., Van Meir, E.G. and Merlo, A. (1999). The PTEN lipid phosphatase domain is not required to inhibit invasion of glioma cells. Cancer Res. 59, 5479-5482

Kessler R., Hamou M-F., Albertoni M., de Tribolet N., Arand M. and Van Meir, E.G. (2000). Identification of the putative brain tumor antigen BF7/GE2 as the (de)toxifying enzyme microsomal epoxide hydrolase. Cancer Res. 60, 1403-1409

Tenan, M., Fulci, G., Albertoni, M., Diserens, A-C., Hamou M-F, El-Atifi-Borel M., Feige, J-J., Pepper, M., and Van Meir, E.G. (2000). Thrombospondin-l is downregulated by hypoxia and suppresses tumorigenicity in human glioblastoma cells. J. Exp. Med. 191, 1789-1798

Fulci, G., Labuhn, M., Maier, D., Lachat, Y., Hausmann, O., Hegi, M.E., Janzer, R.C., Merlo, A. and Van Meir, E.G. (2000). p53 gene mutation and p14Arf deletion are two mutually exclusive events in human glioblastoma. Oncogene 19, 3816-3822

Hao, C., Beguinot F, Condorelli G, Trencia A, Van Meir EG, Yong VW, Parney IF, Roa WH, Petruk KC (2001). Induction and intracellular regulation of TRAIL-induced apoptosis in human malignant glioma cells. Cancer Res. 61, 1162-1170

Labuhn M, Jones G, Speel EJM, Maier D, Zweifel D, Gratzl O, Van Meir EG, Hegi ME, Merlo A (2001). Quantitative real-time PCR does not show selective targeting of p14ARF but concomitant inactivation of both p16INK and p14ARF in 105 human primary gliomas. Oncogene, 20, 1103-1109

Cavallaro U, Tenan M, Castelli V, Perilli A, Maggiano N, Van Meir EG, Montesano R, Soria MR and Pepper M (2001). Response of bovine endothelial cells to FGF-2 and VEGF is dependent on their site of origin: relevance to the regulation of angiogenesis. J. Cell. Bioch. 82, 619-633.

Cheng G, Cao Z, Xu X, Van Meir EG and Lambeth JD (2001). Homologs of gp91phox: cloning and tissue expression of Nox3, Nox4 and Nox5. Gene 269, 131-140.

Ikeda J, Tada M, Ishii N, Saya N, Tsuchiya K, Okaichi K, Mishima K, Fulci G, Van Meir EG (2001). Restoration of wild type p53 activity in a glioblastoma cell line with intrinsic temperature-sensitive p53 induces growth arrest but not apoptosis. Int. J. Cancer 94, 35-43

Post DE and Van Meir EG (2001). Generation of bidirectional hypoxia/HIF-responsive expression vectors to target gene expression to hypoxic cells. Gene Therapy 8, 1801-1807

Kragh M, Quistorff B, Tenan M, Van Meir EG and Kristjansen PEG (2002). Overexpression of thrombospondin-1 reduces vascularity but not perfusion in glioblastoma. Cancer Res 62, 1191-1195

Mabjeesh NJ, Post DE, Willard MT, Kaur B, Van Meir EG, Simons JW and Zhong H (2002). Geldanamycin induces degradation of hypoxia-inducible factor 1a protein via the proteosome pathway in prostate cancer cells. Cancer Res 62, 2478-2482

Fulci, G, Ishii N, Maurici D, Gernert K, Hainaut P, Kaur B and Van Meir EG (2002). Initiation of human astrocytoma by clonal evolution of cells with progressive loss of p53 functions in a patient with a 283H TP53 germline mutation: evidence for a precursor lesion. Cancer Res. 62, 2897-2906 (selected for journal cover)(comment in Cell Death &Differentiation)

Albertoni M, Shaw PH, Nozaki M, Godard S, Tenan M, Hamou MF, Fairlie DW, Breit SN, Paralkar VM, de Tribolet N, Van Meir EG, Hegi ME (2002). Anoxia induces macrophage inhibitory cytokine-1 (MIC-1) in glioblastoma cells independently of p53 and HIF-1. Oncogene 21, 4212-4219

Bratt A, Wilson WJ, Troyanovsky B, Aase K, Kessler R, Van Meir EG and Holmgren L (2002). Angiomotin belongs to a novel protein family with conserved coiled-coil and PDZ binding domains. Gene 298, 69-77

Kaur B, Brat D, Calkins CC, and Van Meir EG (2003). Brain Angiogenesis Inhibitor 1 (BAI1) is differentially expressed in normal brain and glioblastoma independently of p53 expression. Am J Pathol 162, 19-27

Post DE and Van Meir EG (2003). A novel Hypoxia Inducible Factor activated oncolytic adenovirus for cancer therapy. Oncogene 22, 2065-72

Song JH, Song DK, Pyrzynska B, Petruk KC, Van Meir EG and Hao C (2003). TRAIL triggers apoptosis in human malignant glioma cells through extrinsic and intrinsic pathways. Brain Pathol 13, 539-553

Kim EL, Yoshizato K, Meissner H, Zapf S, Nüsing RM, Yamamoto H, Van Meir EG, Deppert W and Giese A (2003). Tumor suppressor p53 inhibits transcriptional activation of the invasion gene thromboxane synthse mediated by the protooncogenic factor Ets-1. Oncogene 22, 7716-27

Cobbs CS, Whisenhunt T, Wesemann DR, Harkins LE, Van Meir EG and Samanta M (2004). Inactivation of wild-type p53 protein function by reactive oxygen and nitrogen species in malignant glioma cells. Cancer Res 63, 8670-73

Brat DJ, Castellano-Sanchez AA, Hunter SB, Pecot M, Cohen C, Hammond EH, Kaur B, Devi SN and Van Meir EG (2004). Pseudopalisading cells in glioblastoma are hypoxic and likely represent an actively migrating population Cancer Res (in press Feb issue)

Yang L, Cao Z, Li F, Post DE, Van Meir EG, Zhong H and Wood WC (2004). Tumor-specific gene expression using the Survivin promoter is further increased by hypoxia Gene Therapy 11, 1215-23 IF: (4.8); cit: 19

Koivisto PA, Zhang X, Sallinen S-L, Sallinen P , Helin HJ, Dong J-T, Van Meir EG, Haapasalo H, Hyytinen E-R, (2004) Absence of KLF6 Gene Mutations in Human Astrocytic Tumors and Cell Lines (letter) Int J Cancer 111, 642-643 IF: (4.7); cit: 4

Ahn J-Y., Rong R, Todd G. Kroll TG, Kalman D, Van Meir EG, Snyder SH and Ye K (2004) PIKE-A GTPase Stimulates Akt Activity and Mediates Cellular Invasion J Biol Chem 279, 16441-16451 IF: (7.0); cit: 13

Stone A, Bobo W, Brat DJ, Devi SN, Van Meir EG and Vertino PM (2004) Aberrant methylation and downregulation of TMS1 in human glioblastoma multiforme Am J Pathol 165, 1151-1161 IF: (5.7): cit: 9

Landen JW, Hau V, Wang M, Davis T, Ciliax B, Wainer B, Van Meir EG, Glass D, Joshi HC and Archer DR (2004) Noscapine crosses the blood-brain barrier and inhibits glioblastoma growth Clin Cancer Res 10, 5187-5201 IF: (5.7); cit: 7

Post DE, Devi NS, Li Z, Brat DJ, Kaur B, Nicholson A, Olson JJ, Zhang Z and Van Meir EG (2004) Cancer therapy with a replicating oncolytic adenovirus targeting the hypoxic microenvironment of tumors. Clin Cancer Res 10, 8603-8612 IF: (5.7); cit: 10

Tan C, de Noronha RG, Roecker AJ, Pyrzynska B, Khwaja F, Zhang Z, Zhang H, Teng Q, Nicholson AC, Giannakakou P, Zhou W, Olson JJ, Pereira MM, Nicolaou KC, and Van Meir EG (2005) Identification of a novel small molecule inhibitor of the hypoxia-inducible factor-1 (HIF-1) pathway. Cancer Res 65, 605-612 IF: (7.6); cit: 29 Featured in the Highlight section and on the journal cover best poster award at 2004 Georgia Life Science Summit

Nicholson AC, Malik S-B, Logsdon JM and Van Meir EG (2005) Functional evolution of ADAMTS genes: evidence from analyses of phylogeny and gene organization BMC Evol Biol 5, 11-23 IF: (4.4); cit: 11

Kaur B, Brat DJ, Devi SN, and Van Meir EG (2005) Vasculostatin, a natural proteolytic fragment of brain angiogenesis inhibitor 1 is an anti-angiogenic and anti-tumorigenic factor Oncogene 24, 3632-3642 IF: (6.8); cit: 9 Georgia Life Science Summit award

Rong Y, Post DE, Pieper RO, Durden DL, Van Meir EG and Brat DJ (2005) PTEN and hypoxia regulate tissue factor expression and plasma coagulation by glioblastoma Cancer Res 65, 1406-1413 IF: (7.6); cit: 17

Li YC, Tzeng CC, Song JH, Tsia FJ, Hsieh LJ, Liao SJ, Tsai CH, Van Meir EG, Hao C and Lin CC (2006) Genomic alterations in human malignant glioma cells associate with the cell resistance to the combination treatment with TRAIL and chemotherapy Clin Cancer Res 12, 2716-2729 IF: (5.7); cit: 0

Khwaja FW, Larkin Nolen JD, Mendrinos SE, Lewis MM, Olson JJ, Pohl J, Van Meir EG, Ritchie JC, Brat DJ (2006) Proteomic analysis of cerebrospinal fluid discriminates malignant and non-malignant disease of the central nervous system and identifies specific protein markers Proteomics 6, 6277-6287 IF: (6.0); cit: 0

Rong Y, Hu F, Huang RP, Mackman N, Horowitz JM, Jensen RL, Durden DL, Van Meir EG and Brat DJ (2006) Egr-1 regulates hypoxia-induced expression of tissue factor in glioblastoma through HIF-1 independent mechanisms Cancer Res 66, 7067-74 IF: (7.6); cit:0

Kang SH, Cho H, Devi SN, Zhang Z, Escuin D, Liang Z, Mao H, Brat DJ, Olson JJ, Simons JW, LaVallee TM, Giannakakou P, Van Meir EG, Shim H (2006) Anti-tumor effect of 2-methoxyestradiol in a rat orthotopic brain tumor model Cancer Res 66, 11991-11997 IF: (7.6); cit:0 Press release

Khwaja FW, Duke-Cohan JS, Brat DJ, and Van Meir EG (2006) Attractin is elevated in the cerebrospinal fluid (CSF) of patients with malignant astrocytoma and mediates glioma cell migration Clin Cancer Res 12, 6331-6336 IF: (5.7); cit: 2 Press release

Khwaja FW, Svoboda P, Reed MS, Pyrzynska B, Pohl J and Van Meir EG (2006) Proteomic identification of the WT-p53 regulated tumor cell secretome Oncogene 25, 7650-7661 IF: (6.8); cit: 0 Press release

Khwaja FW, Reed MS, Olson JJ, Schmotzer BJ, Gillespie GY, Guha A, Groves MD, Kesari S, Pohl J and Van Meir EG (2007) Proteomic identification of biomarkers in the cerebrospinal fluid (CSF) of astrocytoma patients. J Proteome Res 6, 559-570 IF: (6.9); cit: 0 best poster award at 2006 Georgia Life Science Summit best translational poster at WCI 2006 annual symposium Press release

Post DE, Sandberg EM, Devi SN, Brat DJ, Xu Z, Tighiouart M and Van Meir EG (2007) Targeted cancer-gene therapy using a HIF-dependent oncolytic adenovirus armed with interleukin-4 Cancer Res 67, 6872-81 IF: (7.6); cit: 0

Boulay JL, Miserez AR, Zweifel C, Sivasakaran B, Kana V, Ghaffari A, Luyken C, Sabel M, Zerrouqi A, Wasner M, Van Meir EG, Tolnay M, Reifenberger G and Merlo A (2007) Loss of Notch2 positively predicts survival in distinct subgroups of human oligodendroglioma and glioblastoma PloS ONE 6, e576 IF: (); cit: Press release

Kim H-S, Peng G-Y, Hicks J, Van Meir EG, Brenner MK and Yotnda P (2008) Engineering human tumor-specific cytotoxic T cells to function in a hypoxic environment Molecular Therapy (in press) IF: (5.8); cit:

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Review Articles

Wittek R, Bertholet C., Van Meir EG and Garcés J (1988). Regulation of gene expression in Vaccinia virus (in french). UNI Lausanne, 54, 17-19.

Baltuch G., de Tribolet N. and Van Meir EG (1995). Expression of the CD44 adhesion molecule in tumours of the central and peripheral nervous system. J. Neuro-Oncol. 26, 191-198.

Van Meir EG (1995). Genetic alterations involved in human astrocytoma progression and role of the p53 tumor suppressor gene. Bull. Suisse Cancer 15, 111-116.

Van Meir EG and de Tribolet N. (1995). Microsatellite instability in human brain tumors (letter). Neurosurg. 37, 1231-1232.

Van Meir EG (1995). Cytokines and Tumors of the Central Nervous System. Glia 15, 264-288.

Van Meir EG (1996). Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumors (letter). Neurosurg. 39, 878-879.

Paraf F, Jothy S, and Van Meir EG (1997). Brain tumor polyposis syndrome: two genetic diseases? J. Clin. Oncol. 15, 2744-2758.

Dietrich P-Y, Walker P and Van Meir EG (1997). Gene therapy for cancer: an explosion of new therapeutic strategies (in french). Med. & Hygiene 2174, 1527-1535.

Van Meir EG (1998). "Turcot's syndrome": phenotype of brain tumors, survival and mode of inheritance. Int. J. Cancer 75, 162-164.

Hamada J-I, Sawamura Y. and Van Meir EG (1998). CD44 expression and growth factors. Front. Bioscience 3, d657-664.

Fulci G, Ishii N and Van Meir EG (1998). p53 and brain tumors: from gene mutations to gene therapy. Brain Pathol. 8, 599-613.

Francois P. and Van Meir EG (1999). Therapeutic approaches with cytokines for CNS tumors. EOS - J. Immunol. Immunopharmacol. 19, 12-18.

Fulci G and Van Meir EG (1999). p53 and the CNS: tumors and developmental abnormalities. Mol. Neurobiol. 19, 61-77.

Nozaki M. Tada M, Kobayashi H, Zhang C-L, Ikeda J, Sawamura Y, Ishii N and Van Meir EG (1999). Roles of the functional loss of p53 and other genes in astrocytoma tumorigenesis and progression. Neuro-Oncology 1, 124-137

Takeshima H, Sawamura Y, Gilbert MR and Van Meir EG (2000). Application of advances in molecular biology to the treatment of brain tumors. Current Oncol. Report 2, 425-433

Brat D and Van Meir EG (2001). Glomeruloid microvascular proliferation orchestrated by VPF/VEGF. A new world of angiogenesis research. Am. J. Pathol. 158, 789-796

de Fraipont F, Nicholson A, Feige JJ and Van Meir EG (2001). The Thrombospondin family of extracellular matrix proteins: potent inhibitors of tumor angiogenesis. Trends Mol. Medicine 7, 401-407

Brat DJ, Castellano-Sanchez A, Kaur B and Van Meir EG (2002). Genetic and biologic progression in astrocytomas and their relation to angiogenic dysregulation. Adv. Anat. Pathol. 9, 24-36

Brat DJ, Kaur B and Van Meir EG (2002). Genetic modulation of hypoxia-induced gene expression and vascular proliferation: relevance to brain tumors. Front. Biosci. 8, d100-116

Post D.E, Khuri F, Simons JW and Van Meir EG (2003). Replicative oncolytic adenoviruses in multimodal cancer regimens. Hum. Gene Ther. 14, 933-946

Hunter SB, Brat DJ, Olson JJ, von Deimling A, Zhou W and Van Meir EG (2003). Alterations in molecular pathways of diffusely infiltrating glial neoplasms; application to tumor classification and anti-tumor therapy. Int J Oncol 23, 857-869

Post D.E, Fulci G, Chiocca EA, and Van Meir EG (2004). Replicative oncolytic herpes simplex viruses in combination cancer therapies. Current Gene Therapy

Bellail A, Hunter S, Brat DJ and Van Meir EG (2004). Microregional extracellular matrix heterogeneity in brain modulates glioma cell invasion. Int. J. Biochem. & Cell Biol.

Brat DJ and Van Meir EG (2004). Vaso-occlusive and pro-thrombotic mechanisms associated with tumor hypoxia,, necrosis and accelerated growth in glioblastoma. Lab Invest

Van Meir EG, Bellail A and Phuphanich S (2004) Emerging molecular therapies for brain tumors. Semin Oncol 31, 38-46 IF: (3.6); cit: 8

Chu R, Post D.E, Khuri F and Van Meir EG (2004). Use of replicative oncolytic adenoviruses in combination therapy for cancer Clin Cancer Res 10, 5299-5312 IF: (5.7); cit: 21

Kaur B, Tan C, Brat DJ and Van Meir EG (2004) Genetic and hypoxic regulation of angiogenesis in gliomas J Neuro-Oncol 70, 229-243 IF: (2.3); cit: 16

Brat DJ, Bellail A, and Van Meir EG (2005) The role of Interleukin-8 and its receptors in gliomagenesis and tumoral angiogenesis Neuro-Oncol 7, 122-133 IF: (4.1); cit: 23

5th most frequently read article in Neuro-Oncology (May 2006 ranking)

Kaur B, Khwaja FW, Severson EA, Matheny SL, Brat DJ, and Van Meir EG (2005) Hypoxia and the hypoxia-inducible-factor pathway in glioma growth and angiogenesis. Neuro-Oncol 7, 134-153 IF: (4.1); cit: 17 Most frequently read article in Neuro-Oncology (May 2006 ranking)

Post DE, Shim HS, Toussaint-Smith E and Van Meir EG (2005) Cancer Scene Investigation: how a cold virus became a cancer killer Future Oncology 1, 247-258 IF: (n/a); cit: 0

Belozerov V and Van Meir EG (2005) Hypoxia Inducible factor-1: a novel target for cancer therapy Anti-Cancer Drugs 16, 901-909 IF: (1.9); cit: 13

Rong Y, Durden DL, Van Meir EG and Brat DJ (2006) "Pseudopalisading" necrosis in glioblastoma: a familiar morphologic feature that links vascular pathology, hypoxia and angiogenesis J Neuropathol Exp Neurol 65, 529-539 IF: (4.4); cit: 0

Belozerov V and Van Meir EG (2006) Inhibitors of Hypoxia Inducible Factor-1 signaling Current Opinion in Investigational Drugs 7, 1067-1076 IF: (n/a); cit: 0


Symposium Contributions

Van Meir EG and de Tribolet N (1991). "Immunbiologie und Immuntherapie der Gliome" (in German). in Verhandlungen der Deutschen Gesellschaft fur Neurologie. Firnhaber, W., Dworschak, K., Lauer, K., Nichtweiss, M., eds., Springer Verlag (Berlin), 6, 410-415.

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Book Chapters

Tada M, Diserens A-C, Hamou M-F, Jaufeerally R, Van Meir EG, and de Tribolet N (1996). Suppressed expression of T-cell costimulatory molecules B7 and B70 in human glioblastoma in vivo. In Brain Tumor Research and Therapy , M. Nagai, ed., Springer-Verlag (Tokyo), 327-337.

De Stasio G, Gilbert B, Andres R, Lorusso GF, Redondo J, Van Meir EG, Brunet J-F, Droubay TC, Tonner BP, Mercanti D, Ciotti MT, Suda T, Perfetti P and Margaritondo G (1997). Synchrotron spectromicroscopy for microchemical analysis of boron in rat brain tumor treated with BSH. In Advances in Neutron Capture Therapy, volume II, Chemistry and Biology, B. Larsson, J. Crawford and R. Weinreich (eds.). Elsevier Science, (ExcerptaMedica. International congress series 1132) pp. 321-326.

Van Meir EG, Oosterhuis JW and Looijenga L (1998). Genesis and genetics of intracranial germ cell tumors. In Intracranial germ cell tumors, Sawamura, Y., Shirato, H. and de Tribolet, N. (eds.), Springer Verlag, Wien, New York pp. 45-76

Van Meir EG (1999). Cytokine expression in brain tumors: its role in tumor biology and tumor-associated immune responses. In Inflammatory Cells and Mediators in CNS Diseases, Ruffolo RRJr., Feuerstein GZ, Hunter AJ, Poste G, and Metcalf BW(eds.), Harwood Academic Publishers, London. pp. 169-244

Rosenblum MK, Matsutani M, and Van Meir EG (2000). Central nervous system germ cell tumors. In Tumors of the Nervous System. Kleihues, P. and Cavenee, W.K. (eds.), World Health Organization Classification of Tumors, International Agency for Research on Cancer, Lyon p.207-214

Cavenee WK, Burger PC and Van Meir EG (2000). Turcot syndrome. In Tumors of the Nervous System. Kleihues, P. and Cavenee, W.K. (eds.), World Health Organization Classification of Tumors, International Agency for Research on Cancer, Lyon p.238-239

Van Meir EG, Hao C, Post DE, Liau L and Brat DJ (2003). Therapeutic targeting of molecular pathways that induce brain tumor development. In Genomic and Molecular Neuro-Oncology. Zhang W. and Fuller GN (eds.) Jones and Bartlett Publishers Inc. p.303-331

Dey, N, Durden DL and Van Meir EG (2006) Cytokine expression and signaling in CNS tumors. In Cytokines and the CNS II. Benveniste EN and Ransohoff RM (eds) CRC Press. p.193-242.

Cavenee WK, Burger PC, Leung SY and Van Meir EG (2007) Turcot syndrome. In WHO Classification of Tumors of the Central Nervous System. Louis D, Ohgaki H, Wiestler O and Cavenee, W.K. (eds.), International Agency for Research on Cancer, Lyon p.229-231

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Manuals, videos, computer programs, media relations and other teaching aids:

Research on p53 secretome featured in Science Daily (Oct 27, 2006)
http://www.sciencedaily.com/releases/2006/10/061025180249.htm

Research on p53 secretome featured in Medical News Today (Oct 28, 2006)
http://www.medicalnewstoday.com/medicalnews.php?newsid=55141

Research on p53 secretome featured in Emory Report (Oct 30, 2006)
http://www.emory.edu/EMORY_REPORT/erarchive/2006/October/October%2030/SandRWinship.htm

Research on attractin featured in SAWF NEWS (Nov 10, 2006)
http://news.sawf.org/Health/26788.aspx

Research on attractin featured in bio.com (Nov 10, 2006)
http://www.bio.com/newsfeatures/newsfeatures_research.jhtml?cid=23500019

Research on attractin featured in Virtual trials (Nov 11, 2006)
http://virtualtrials.com/news3.cfm?item=3707

Research on attractin featured in Medical News Today (Nov 11, 2006)
http://www.medicalnewstoday.com/medicalnews.php?newsid=56389

Research on attractin featured in Science Daily (Nov 13, 2006)
http://www.sciencedaily.com/releases/2006/11/061112094644.htm

Research on attractin featured in Neuroscience News Network (Nov 15, 2006)

Research on attractin featured in Playfuls (Nov 16, 2006)
http://www.playfuls.com/news_002946_Biomarker_Detects_Regulates_Brain_Tumors.html

Research on attractin featured in Physorg (Nov 16, 2006)
http://www.physorg.com/news82923017.html

Research on attractin featured in Dental Plans (Nov 16, 2006)
http://www.dentalplans.com/articles/5997/

Research on attractin featured in HealthNewsDigest (Nov 17, 2006)
http://healthnewsdigest.com/news/article_4795.shtml

Research on attractin featured in BioCentury Extra (Nov 17, 2006)

Research on attractin featured in Emory Report (Nov 27, 2006)
http://www.emory.edu/EMORY_REPORT/erarchive/2006/November/November%2027/S&RBiomarker.htm

Research on attractin featured in Hematology & Oncology News & Issues 5, 17-17 (Dec 2006)

Research on attractin featured in Cancer Weekly (Dec 5, 2006)
http://www.newsrx.com/cgi-bin/samplepdf.cgi?filename=cw.pdf Research on attractin featured in World News
http://1-news.org/world-news/Newly-Identified-Biomarker-Detects-and-Regulates-Spread-of-Brain-Tumors/

Research on attractin featured in Science News Den (Dec 2006)
http://www.sciencenewsden.com/2006/newlyidentifiedbiomarkerdetectsandregulatesspreadofbraintumors.shtml

Research on attractin featured in CprMap
http://www.cprmap.com/faq.php

Research on attractin featured in DRIC (drug research information center)
http://dric.sookmyung.ac.kr/trend/recent_news_detail.html?id=258

Research on attractin featured in Bioguider
http://www.bioguider.com/en/news/Neurosci/200611/24722.shtml

Research on attractin featured in Bioon
http://www.bioon.com/biology/Class18/242794.shtml

Research on attractin featured in Iconoclast
http://www.iconocast.com/News_Files/A1SW0/News7.htm

Research on 2ME2 featured in Yahoo Finance
http://biz.yahoo.com/prnews/061221/dcth009.html?.v=76

Press release on research on new markers in the CSF of brain tumor patients
http://whsc.emory.edu/press_releases2.cfm?announcement_id_seq=8900

Research on new markers in the CSF of brain tumor patients featured in Emory Report
http://www.emory.edu/EMORY_REPORT/erarchive/2007/February/February%205/research_roundup.htm

Research on new markers in the CSF of brain tumor patients featured in Health Orbit
http://healthorbit.ca/NewsDetail.asp?opt=1&nltid=096290107

Research on attractin featured in EMORY Medicine, summer 2007, p6

Research on Notch2 featured in Science Daily (June 27, 2007)
http://www.sciencedaily.com/releases/2007/06/070627091626.htm

Research on Notch2 featured in Neuroscience News Network, (July 17, 2007)