Professor and Vice Chair, Department of Neurosurgery Director, Molecular Neurosurgery and Biotechnology Laboratory Program Director, Neurosurgery Residency Program 1365B Clifton Rd., NE, Ste. 6200 Atlanta, GA 30322 Appt. Phone: 404-778-5770

• Areas of Clinical Interest
• Publications
• Manuscripts in Review
• Manuscripts in Preparation
• Review Articles
• Book Chapters
• Books
• Media Credits / Press Releases
• Research
• Brain Tumor Program
• Endocrine Pituitary Clinic

Dr. Oyesiku received his medical degree from the University of Ibadan in Nigeria. He completed his neurosurgical residency training at Emory, where he also earned his PhD in neuroscience. Dr. Oyesiku's clinical interests are pituitary tumors and stereotactic radiosurgery. He is actively pursuing research on the molecular biology of pituitary tumors. His laboratory has identified unique aspects of pituitary tumor gene expression and is developing a new modality for imaging and targeted therapy of pituitary tumors.

Dr. Oyesiku is board certified in Neurological Surgery and is a fellow of the American College of Surgeons.


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Areas of Clinical Interest:

• pituitary tumors
• stereotactic radiosurgery

Publications

Oyesiku N.M., Jones R.K.: Migration of a Heifetz aneurysm clip to the caudal equina causing lumbar radiculopathy. Case Report and Review of the Literature. J Neurosurgery 65: 256-257, 1986.

Oyesiku N.M., Gahm N.H., Goldman R.L.: Cerebral arteriovenous fistula in the Klippel-Trenaunay-Weber syndrome: Case Report and Review of the Literature. Developmental Medicine and Child Neurology 30:245-248, 1988.

Oyesiku N.M., Barrow D.L., Eckman J.R., Tindall S .C., Colohan A.R.T. Intracranial Aneurysms in Sickle Cell Anemia: Clinical features and pathogenesis. J Neurosurgery 75: 356-363, 1991.

Colohan AR., Oyesiku N.M. Moderate head injury: an overview. J Neurotrauma. 9 Suppl 1:S259-64, 1992.

Oyesiku N.M., Colohan A.R.T., Barrow D.L., Reisner A. Cocaine-induced aneurysmal rupture: an emergent negative factor in the natural history of intracranial aneurysms? Neurosurgery, 32:518-526, 1993.

Tindall G.T., Oyesiku N.M., Watts N.B, Clark R.V., Christy J., Adams D.A. Transsphenoidal Microsurgical Adenomectomy of Growth Hormone-Secreting Adenomas in Acromegaly: Outcome Analysis and Determinants of Failure. J Neurosurgery, 78:205-215, 1993.

Oyesiku N.M., Wigston D.J. CNTF stimulates neurite outgrowth from spinal cord neurons. J Comp. Neurol, 364:68-77, 1996.

Oyesiku N.M. Intracranial Aneurysms in Sickle Cell Anemia: Clinical Management. GSMA Quarterly 7- 9, 1996.

Oyesiku N.M., Wilcox , J.N., Wigston D.J. Changes in expression of CNTF and CNTFRa after spinal cord injury. J Neurobiol, 251-261, 1997.

Oyesiku N.M., Evans C-O, Parks, J.S, Brown, M.S., Tindall G.T. Pituitary adenomas: screening for Gaq mutations. J of Clinical Endocrinology and Metabolism 82:4184-4188, 1997.

Oyesiku N.M., Evans, C-O, Houston S, Darrell, R.S., Smith J.S, Fulop, Z.L.,Dixon, C. Edward, Stein, D.G. Regional changes in expression of neurotrophic factors and their receptors after traumatic brain injury in the adult rat brain. Brain Research 833: 161-172, 1999.

Evans, C-O, Oyesiku N.M., Brown, M.S , Parks, J.S. Screening for MEN-I Tumor Suppressor Gene Mutations in Sporadic Pituitary Tumors. J Endocrinological Investigation 23:304-309, 2000.

Schultz A., Brat DJ, Oyesiku N.M., Hunter S., Intrasellar Pituitcytoma in a patient with other endocrine neoplasms Archives of Pathology and Laboratory Medicine 125: 527-530, 2001.

Evans C-O, Young A N, Brown MR, Brat DJ, Parks JS, Neish AS, Oyesiku N.M. Novel patterns of gene expression in pituitary adenomas identified by cDNA microarrays and quantitative RT-PCR. Journal of Clinical Endocrinology and Metabolism, 86: 3097-3107, 2001.

Biousse V., Newman, N.J., Oyesiku, N.M. Precipitating factors in pituitary apoplexy. J Neurol Neurosurg Psychiatry, 71:542-545, 2001.

Alleyne C.H. Jr., Barrow, D.L., Oyesiku N.M. Combined transsphenoidal and pterional craniotomy approach to giant pituitary tumors. Surgical Neurology 57:380-390, 2002.

Hadley M.N., Walters B.C., Grabb P.A., Oyesiku, N.M., Przybylski, G.J., Resnick D.K., Ryken T. C., Guidelines for Management of Acute Cervical Spinal Injuries, Neurosurgery 50:S1-6, 2002.

Hadley M.N., Walters B.C., Grabb P.A., Oyesiku, N.M., Przybylski, G.J., Resnick D.K., Ryken T. C., Cervical Spine Immobilization before Admission to the Hospital, Neurosurgery 50:S7-17, 2002.

Hadley M.N., Walters B.C., Grabb P.A., Oyesiku, N.M., Przybylski, G.J., Resnick D.K., Ryken T. C., Transportation of Patients with Acute Traumatic Cervical Spine Injuries, Neurosurgery 50:S18-20, 2002.

Hadley M.N., Walters B.C., Grabb P.A., Oyesiku, N.M., Przybylski, G.J., Resnick D.K., Ryken T. C., Clinical Assessment after Acute Cervical Spinal Cord Injury, Neurosurgery 50:S21-29, 2002.

Hadley M.N., Walters B.C., Grabb P.A., Oyesiku, N.M., Przybylski, G.J., Resnick D.K., Ryken T. C., Radiographic Assessment of the Cervical Spine in Asymptomatic Trauma Patients, Neurosurgery 50:S30-35, 2002.

Hadley M.N., Walters B.C., Grabb P.A., Oyesiku, N.M., Przybylski, G.J., Resnick D.K., Ryken T. C., Radiographic Assessment of the Cervical Spine in Symptomatic Trauma Patients, Neurosurgery 50:S36-43, 2002.

Hadley M.N., Walters B.C., Grabb P.A., Oyesiku, N.M., Przybylski, G.J., Resnick D.K., Ryken T. C., Initial Closed Reduction of Cervical Spine Fracture-Dislocation Injuries, Neurosurgery 50:S44-50, 2002.

Hadley M.N., Walters B.C., Grabb P.A., Oyesiku, N.M., Przybylski, G.J., Resnick D.K., Ryken T. C., Management of Acute Spinal Cord Injuries in an Intensive Care Unit or Other Monitored Setting, Neurosurgery 50:S51-57, 2002.

Hadley M.N., Walters B.C., Grabb P.A., Oyesiku, N.M., Przybylski, G.J., Resnick D.K., Ryken T. C., Blood Pressure Management after Acute Spinal Cord Injury, Neurosurgery 50:S58-62, 2002.

Hadley M.N., Walters B.C., Grabb P.A., Oyesiku, N.M., Przybylski, G.J., Resnick D.K., Ryken T. C., Pharmacological Therapy after Acute Cervical Spinal Cord Injury, Neurosurgery 50:S63-72, 2002.

Hadley M.N., Walters B.C., Grabb P.A., Oyesiku, N.M., Przybylski, G.J., Resnick D.K., Ryken T. C., Deep Venous Thrombosis and Thromboembolism in Patients with Cervical Spinal Cord Injuries, Neurosurgery 50:S73-80, 2002.

Hadley M.N., Walters B.C., Grabb P.A., Oyesiku, N.M., Przybylski, G.J., Resnick D.K., Ryken T. C., Nutritional Support after Spinal Cord Injury, Neurosurgery 50:S81-84, 2002.

Hadley M.N., Walters B.C., Grabb P.A., Oyesiku, N.M., Przybylski, G.J., Resnick D.K., Ryken T. C., Management of Pediatric Cervical Spine and Spinal Cord Injuries, Neurosurgery 50:S85-99, 2002.

Hadley M.N., Walters B.C., Grabb P.A., Oyesiku, N.M., Przybylski, G.J., Resnick D.K., Ryken T. C., Spinal Cord Injury without Radiographic Abnormality, Neurosurgery 50:S100-104, 2002.

Hadley M.N., Walters B.C., Grabb P.A., Oyesiku, N.M., Przybylski, G.J., Resnick D.K., Ryken T. C., Diagnosis and Management of Traumatic Atlanto-occipital Dislocation Injuries, Neurosurgery 50:S105-113, 2002.

Hadley M.N., Walters B.C., Grabb P.A., Oyesiku, N.M., Przybylski, G.J., Resnick D.K., Ryken T. C., Occipital Condyle Fractures, Neurosurgery 50:S114-119, 2002.

Hadley M.N., Walters B.C., Grabb P.A., Oyesiku, N.M., Przybylski, G.J., Resnick D.K., Ryken T. C., Isolated Fractures of the Atlas in Adults, Neurosurgery 50:S120-124, 2002.

Hadley M.N., Walters B.C., Grabb P.A., Oyesiku, N.M., Przybylski, G.J., Resnick D.K., Ryken T. C., Isolated Fractures of the Axis in Adults, Neurosurgery 50:S125-139, 2002.

Hadley M.N., Walters B.C., Grabb P.A., Oyesiku, N.M., Przybylski, G.J., Resnick D.K., Ryken T. C., Management of Combination Fractures of the Atlas and Axis in Adults, Neurosurgery 50:S140-147, 2002.

Hadley M.N., Walters B.C., Grabb P.A., Oyesiku, N.M., Przybylski, G.J., Resnick D.K., Ryken T. C., Os Odontoideum, Neurosurgery 50:S148-155, 2002. Hadley M.N., Walters B.C., Grabb P.A., Oyesiku, N.M., Przybylski, G.J., Resnick D.K., Ryken T. C., Treatment of Subaxial Cervical Spinal Injuries, Neurosurgery 50:S156-165, 2002.

Hadley M.N., Walters B.C., Grabb P.A., Oyesiku, N.M., Przybylski, G.J., Resnick D.K., Ryken T. C., Management of Acute Central Cervical Spinal Cord Injuries, Neurosurgery 50:S166-172, 2002.

Hadley M.N., Walters B.C., Grabb P.A., Oyesiku, N.M., Przybylski, G.J., Resnick D.K., Ryken T. C., Management of Vertebral Artery Injuries after Nonpenetrating Cervical Trauma, Neurosurgery 50:S173-178, 2002.

Hadley M.N., Walters B.C., Grabb P.A., Oyesiku N.M., Przybylski G.J., Resnick D.K., Ryken T.C., Mielke DH. Guidelines for the management of acute cervical spine and spinal cord injuries. Clinical Neurosurgery. 49:407-98, 2002.

Evans, C-O, Reddy, P, Brat D.J., O'Neill E.B., Branch B., Stevens, V.L., Oyesiku, N.M., Differential Expression of Folate Receptor in Pituitary Adenomas, Cancer Research 63:4218-4224, 2003.

Zhan, X, Evans, C-O, Oyesiku, N.M., Desiderio D Proteomics and transcriptomics analyses of secretagogin down regulation in human non-functional pituitary adenomas. Pituitary 6: 189-202, 2004

Jun He; Evans, C-O, Stuart W. Hoffman; Oyesiku, N.M, Donald Stein Progesterone and Allopregnanolone Reduce Inflammatory Cytokines after Traumatic Brain Injury. Experimental Neurology, 189:404-412, 2004

Oyesiku, N.M., Halkar R. K., Galt J. R., Faraj B. A., Evans C.O. SPECT/CT of FolateScan ( Tc-99m EC20) in pituitary tumors: A novel imaging tracer and Technique. Journal of Nuclear Medicine Vol 45 (5 S) 368P 2004

Evans C-O, Young A N, Brown MR, Brat DJ, Parks JS, Neish AS, Oyesiku N.M. Novel patterns of gene expression in pituitary adenomas identified by complementary deoxyribonucleic acid microarrays and quantitative reverse transcription-polymerase chain reaction. Oncomine Cancer Microarray Database (www.oncomine.org).

Todd J. Scarbrough T.J, Crocker I.R., Davis L.W., Barrow D.L., Fowler B.Z., Oyesiku N.M. Intracranial Arteriovenous Malformations Treated Utilizing a Linear Accelerator-Based Patient Rotator or Commercially Available Radiosurgery System. Stereotactic and Functional Neurosurgery 83:91-100, 2005.

Moreno C, Evans C-O, Okor M; Desiderio, D.M., Oyesiku N.M. Novel Molecular Signaling in Human Clinically Non-Functional Pituitary Adenomas by Gene Expression Profiling. Proceedings of the 13th World Congress of Neurological Surgery, Marrakech, Morocco, Medimond International Proceedings, pg 1151-1156, 2005, Medimond S.r.l., Bologna, Italy

Evans C-O, Halkar, R.K., Galt, J.R., Faraj, B.J. Oyesiku, N.M. Molecular Targeting and Imaging of Non- Functional Pituitary Tumors: Preliminary Results. Jpn J Neurosurg 15:437-443, 2006

Oyesiku NM. 2005 Congress of Neurological Surgeons Presidential Address. Homogeneity and heterogeneity: lessons from nature and society. Clinical Neurosurgery. 53:1-9, 2006.

Manuscripts in review


Manuscripts in Preparation

Evans C-O, Moreno C., Desiderio, D.M, Oyesiku N.M. Prolactinomas: gene expression analysis by microarrays, quantitative RT-PCR and proteomics.

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Review Articles

Oyesiku N.M., Tindall G.T.: Neurosurgery - The year in Review -1988. Contemporary Neurosurgery Vol. 10., No. 27, 1989.

Oyesiku N.M., Colohan A.R.T. Moderate Head Injury: An Overview In NIH CNS Trauma Status Report, p 259-264, 1992.

Oyesiku, N.M. Management of Growth Hormone Secreting Adenomas: An Update, Thieme, 2002

Book Chapters

Oyesiku N.M., Bakay R.A.E.: CNS Transplantation. In Neurosurgery - The Scientific Basis of Clinical Practice. Ed. 2., Crockard H.A., Hayward R.D, Hoff J.T. (eds) Blackwell Scientific Publications, Oxford. 1992 pp 448-469.

Oyesiku N.M., Barrow DL: Infectious, Traumatic and other Unusual Aneurysms. In: Current Treatment of Aneurysms. AANS Publications. William's and Wilkin's, Baltimore, pp 243-275,1993.

Oyesiku N.M., Bakay R.A.E., Surgery for Spinal Tumors. In Medical Care of the Surgical Patient, J.P. Lippincott, Philadelphia 1995 pp 602-604.

Oyesiku N.M.,., Tindall G.T.,: Pituitary Gland: Surgery A Problem Solving Approach, (ed. 2), John H. Davis, George F. Sheldon, C.V. Mosby, St Louis, 1995 pp 2363-2396.

Oyesiku N.M., Tindall G.T.: Management of Hypersecreting Pituitary Tumors. In The Practice of Neurosurgery Tindall G.T., Cooper P.R., Barrow D.L. (eds) William's and Wilkin's, Baltimore, 1996 pp 11351152.

Oyesiku N.M., Tindall G.T., Pituitary Tumors: Principles and Practice of Neurosurgical Critical Care. William's and Wilkin's, 1996.

Oyesiku N.M., Tindall G.T.: Endocrine-Inactive adenomas: surgical results and prognosis. In Pituitary Adenomas Landolt A.M., Vance, M.L., Reilly, P.L. (eds) Churchill-Livingstone, New York,1996 pp 377-383.

Barrow D.L., Oyesiku N.M., Distal Anterior Cerebral Aneurysms. In Neurosurgery Wilkin's and Rengachary (eds), William's and Wilkin's, pp 2327-2331, 1996.

Oyesiku N.M.,. Pituitary Tumors and Sheehan's Syndrome in Pregnant Women. In: Neurosurgical Aspects of Pregnancy. AANS Publications pp 77-84, 1996.

Oyesiku N.M.,., Alleyne C, G.T Tindall. Combined pterional and transsphenoidal approach to pituitary tumors. 1998 (in Pituitary Disorders: Comprehensive management Krisht AF & Tindall GT) Lippincott Williams & Wilkins, Baltimore, 1999 pp 369-373.

Oyesiku N.M., Alleyne C., Schwartzman S. Fungal infections of the Brain pp 123-139. In: Infections in Neurological Surgery. Osenbach R., Zeidman S. (Eds). Lippincott-Raven. 1999.

Olson JJ, Barrow, DL, Gilbert, MR, Oyesiku N.M., Intracranial Tumors in. Oxford Textbook of Surgery, 2000 Chap 44.3, 2801-2828.

Resnick, D.K., Oyesiku N.M.,. Assessment and Classification of Spinal Cord Injuries. In Neurotrauma: Evidence Based Answers to Common Questions Valadka A, and Andrews B. (Eds.)2002.

Oyesiku N.M., What is the best way to assess and classify head-Injured patients? In Neurotrauma: Evidence Based Answers to Common Questions Valadka A, and Andrews B. (Eds.) 2002.

Oyesiku N.M., Pathophysiology and Management of Endocrine Function, In Textbook of Neurological Surgery: Principles and Practice. Lippincott Williams & Wilkins, Philadelphia Batjer, HH & Loftus, CM (Eds), pp 713-725.

Oyesiku N.M., Clinically Nonfunctional Adenomas. In: Principles of Neurosurgery (2nd Ed) Ellenbogen, R & Rengachary, S (Eds) Elsevier 2002.

Oyesiku N.M., Assessment of Pituitary Function. In: Principles of Neurosurgery (2nd Ed) Ellenbogen and Rengachary, Elsevier 2002.

Oyesiku N.M. Transsphenoidal Surgery. In Medical Care of the Surgical Patient, (3rd Ed) Lubin, Walker, & Smith -Eds., J.P. Lippincott, Philadelphia, 2003

Evans C-O, Moreno C., Oyesiku N.M. Novel Molecular Signaling and Classification in Human Clinically Non-Functional Pituitary Adenomas Identified by Microarray and Reverse Transcription-Quantitative Polymerase Chain Reaction. In Contemporary Endocrinology: Genomics in Endocrinology: DNA Microarray Analysis in Endocrine Health and Disease. Edited by S.Handwerger and B. Aronow, Humana Press, Totowa, NJ, 2007

Books

Oyesiku N.M., Amacher A.L. Patient Care in Neurosurgery 3rd Edition. Boston/Toronto. Little, Brown & Company, 1990.

Oyesiku N.M., Amacher A.L. Patient Care in Neurosurgery (Japanese Language Edition). Medical Sciences International Ltd. Tokyo, 1992.

Barrow DL, Tindall SC, Oyesiku N.M., Washington J, Hunter SB, Owens DS, Harper FN (eds). Neurosurgery Board Review, Questions and Answers for Self-Assessment, Alleyne CH Jr. New York/Stuttgart, Thieme 1997.

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Media Credits / Press Releases

Cutting-Edge Brain Surgery Without The Scalpel 4-17-2000
http://www.sciencedaily.com/releases/2000/04/000417095440.htm

'Beam shaper' sharpens brain surgeons' aim Emory Report April 24, 2000 Volume 52, No. 30
http://www.emory.edu/EMORY_REPORT/erarchive/2000/April/erapril.24/4_24_00beam_shaper.html

Emory University Tests Safety and Effectiveness of Device for the Possible Treatment of Alzheimer's Disease. March 2002
http://www.whsc.emory.edu/_releases/2002march/cognishunt.html

Emory Offers New Targeted Radiation Treatment for Brain Tumors with First Machine of its Kind. Oct 6, 2004
http://www.whsc.emory.edu/press_releases2.cfm?announcement_id_seq=1820

Dr. Nelson Oyesiku comments on a non-invasive procedure for treatment of brain tumors. WLVI-WB Boston, MA, Science Daily, Capital News 9. 10/9/04-10/14/04
http://www.whsc.emory.edu/emory_in_the_news_2004_10_15.cfm

Emory doctors, neurosurgeon Nelson Oyesiku interviewed about a new noninvasive surgical procedure for treatment of brain tumors. CNN, CLTV-CABLE Chicago IL, WLOS-ABC Greenville SC 10/6/04
http://www.whsc.emory.edu/emory_in_the_news_2004_10_08.cfm

Emory Offers New Targeted Radiation Treatment for Brain Tumors with First Machine of its kind. http://www.emoryhealthcare.org/departments/business_advantage/On-board_Imagin_Release.html

Emory Offers New Targeted Radiation Treatment for Brain Tumors with First Machine of its Kind.10/12/2004
http://virtualtrials.com/news3.cfm?item=2813

Emory studies COGNIShunt device for Alzheimer's treatment 21-Mar-2002
http://www.eurekalert.org/pub_releases/2002-03/euhs-esc032102.php May 2001
http://www.healthboards.com/boards/showthread.php?t=14059

An alternative to cancer treatment Capital News 9 Health Team 9, Atlanta, GA
http://www.capitalnews9.com/content/health_team_9/Default.asp?ArID=99026&SecID=17&addvid=46024

Emory Researchers Awarded $1.6 Million to Study Common Type of Pituitary Tumor
http://www.whsc.emory.edu/press_releases2.cfm?announcement_id_seq=3463

Emory Neurosurgeon Elected President of Congress of Neurological Surgeons
http://www.whsc.emory.edu/press_releases2.cfm?announcement_id_seq=3239

Atlanta Business Chronicle April 22-28, 2005 KUDOS Nelson M. Oyesiku, M.D., a professor of neurosurgery at Emory University School of Medicine, has been elected president of the Congress of Neurological Surgeons.
http://atlanta.bizjournals.com/atlanta/stories/2005/04/25/newscolumn5.html?page=2