Professor, Department of Neurosurgery Director, Clinically-related Neuro-oncology Laboratory Co-director, Brain Tumor Program 1365B Clifton Rd., NE, Ste. 6200 Atlanta, GA 30322 Appt. Phone: 404-778-5770

• Areas of Clinical Interest
• Publications
• Research
• Brain Tumor Program

Dr. Olson received his MD from the University of Minnesota. He underwent his neurosurgical residency training at the University of Iowa, followed by 3 years as a Senior Staff Fellow at the National Institutes of Health in Bethesda, Maryland. His primary interest is in neuro-oncology, with significant laboratory effort investigating drug delivery modulation of tumor proliferation. Dr. Olson's neurosurgical practice and research revolve around the biology and therapy of brain tumors. Patients with primary malignant brain tumors offer an excellent opportunity to carry out clinical research. Emory's multidisciplinary neuro-oncology team utilizes a number of therapeutic protocols designed to take advantage of the molecular and anatomic characteristics of brain tumors. Input from professionals with basic science, medical oncology, neurology, radiology, radiation oncology and neurosurgical backgrounds afford the patient and the neurosurgical trainee the best exposure to the therapeutic options available in a wide variety of cases.


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Areas of Clinical Interest: acoustic neuroma brain tumors (Emory PI for the NCI-sponsored New Approaches to Brain Tumor Therapies-CNS Consortium) cerebrospinal fluid leakage cranial nerve disorder lesions of the anterior and posterior skullbase stereotactic surgery

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Publications

Olson JJ, Shepherd S, Bakay RAE: The EasyGuideTM Neuro Image-Guided Surgery System. Neurosurgery 40:1092-1095, 1997.

Chen W, He J, Olson JJ, Lu R: Carboplatin-loaded PLGA microspheres for intracerebral implantation: in vivo characterization. Drug Delivery 4:301-311, 197.

Alleyne C, Olson JJ, Bakay RAE, Fox T, Crocker I, Cotsonis G: Stereotactic radiosurgery of malignant and benign intracranial lesions utilizing a patient rotator. Radiation Oncology Investigations 5:20-30, 1997.

Olson JJ, Barnett D, Yang J, Assietti R, Cotsonis G, James CD: Gene amplification as a prognostic factor in primary brain tumors. Clinical Cancer Research 4:215-222, 1998.

Chen W, He J, Olson JJ, Lu R: Brain tissue reaction following intracerebral injection of free or liposomally encapsulated BSH. Drug Delivery 5:1-10, 1998.

Shoup TM, Olson JJ, Hoffman JM, Votaw J, Eshima D, Camp VM, Votaw D, Goodman MM: Synthesis and evaluation of {18F}-1-amino-3-fluoro-cyclobutane-1-carboxylic acid to image brain tumors. Journal of Nuclear Medicine 40:331-338, 1999.

Alleyne CH, He J, Yang J, Hunter SB, Cotsonis G, James CD, Olson JJ: Analysis of cyclin dependent kinase inhibitors in malignant astrocytomas. International Journal of Oncology 14:1111-1116, 1999.

James CD, Galanis E, Frederick L, Kimmel DW, Cunningham JM, Atherton-Skaff PJ, O'Fallon JR, Jenkins RB, Buckner JC, Hunter SB, Olson JJ, Scheithauer BW: Tumor suppressor gene alterations in malignant gliomas: histopathological associations and prognostic evaluation. International Journal of Oncology 15:547-553, 1999.

Yung WKA, Prados MD, Yay-Tur R, Rosenfield SS, Brada M, Fredman HS, Albright R, Olson JJ, Chang SM, O'Neill AM, Friedman AH, Burner, Yue N, Dugan M, Zakonoen S, Levin VA: Multicenter phase II trial of temozolomide in patients with anaplastic astrocytoma or anaplastic oligoastrocytoma at first relapse. Journal of Clinical Oncology 17:2762-2771, 1999.

Schinazi RF, Hurwitz SJ, Liberman I, Juodawkis A, Shi J, Liotta DC, Coderre J, Olson JJ: ß-5-o-carboranyl-2'-deoxyuridine for the treatment of malignant brain tumors. Clinical Cancer Research 6:725-730, 2000.

Trounce I, Schmiedel J, Yen H-C, Hosseini S, Brown MD, Olson JJ, Wallace DC: Cloning of neuronal mtDNA variants in cultured cells by synaptosome fusion with mtDNA-less cells. Nucleic Acids Research 28:2164-2170, 2000.

Houston SC, Crocker IR, Brat DJ, Olson JJ: Extraneural metastatic glioblastoma after interstitial brachytherapy. International Journal of Radiation Oncology, Biology, Physics, April 2000.

Yung WKA, Albright RE, Olson JJ, Fredericks R, Fink K, Prados M, Spene A, Hohl RJ, Shapiro W, Glantz M, Greenberg H, Selker RG, Vick NA, Rampling R, Friedman H, Phillips R, Bruner J, Yue N, Osaba D, Zaknoen S, Levin Va: A phase II study of temozolomide vs. procarbazine in patients with glioblastoma at first relapse. British Journal of Cancer, May 2000.

Sharara N, Muller S, Olson J, Grist WJ, Grossniklaus HE: Sinonasal undifferentiated carcinoma with orbital invasion. Ophthalmic Plastic and Recon Surg 4: 288-292, 2001

Stubbs J, Frankel R, Schultz K, Crocker I, Dillehay D, Olson JJ: Pre-clinical evaluation of a novel device for delivering brachytherapy to resected brain tumor cavity margins. J Neurosurg 96: 335-343, 2002.

Hunter S, Young A, Olson J, Brat DJ, Bowers G, Wilcox JN: Differential expression between pilocytic and anaplastic astrocytoma: identification of apoplipoprotein D as a marker for low-grade, non-infiltrating primary CNS neoplasms. J Neuropathol Exp Neurol 61: 275-281, 2002.

McConathy J, Martello L, Malveaux EJ, Camp VM, Simpson NE, Simpson, Bowers GD, Olson, JJ, Goodman MM: Radiolabeled amino acids for tumor imaging with PET: Radiosynthesis and biological evaluation of 2-amino-3-[18F]fluoro-2-methylpropanoic acid and 3-[18F]fluoro-2-methyl-2-(methylamino)propanoic acid. J Med Chem 45: 2240-2249, 2002.

Selker RG, Shapiro W, Burger P, Blackwood, Deutsch M, Arena V, Van Gilder JC, Wu J, Malkin M, Mealey J, Jr, Neal J, Olson J, Robertson JT, Barnett G, Bloomfield S, Albright R, Hochberg FH, Heisigner E, Green S: The Brain Tumor Cooperative Group NIH Trial 87-01: A randomized comparison of surgery, external radiotherapy and BCNU v. surgery, interstitial radiotherapy boost, external radiation therapy and BCNU. Neurosurgery 51:343-357, 2002.

Mayr MT, Crocker IR, Butker EK, Williams WH, Cotsonis GA, Olson JJ: Results of interstitial brachytherapy for malignant brain tumors. Int J Oncol. 21:817-823, 2002.

Martarello L, McConathy J, Camp VM, Malveaux EJ, Simpson NE, Simpson CP, Olson JJ, Gowers GD, Goodman MM: Synthesis of syn- and anti-1-Amino-3-[18F]fluoromethyl-cyclobutane-1-carboxylic Acid (FMACBC), Potential PET Ligands for Tumor Detection. J Med Chem 45: 2250-2259, 2002.

Gilbert MR, Friedman HS, Kuttesch JF, Prados MD, Olson JJ, Reaman GH, Zakonen SL: A Phase II Study of Temozolomide in Patients With Newly Diagnosed, Supratentorial Malignant Glioma Prior to Radiation Therapy. Neuro-Oncology: 261-267, October, 2002.

Losner RR, Walbridge S, Vortmeyer AO, Pack SD, Nguyen TT, Gogate N, Olson JJ, Akbasak A, Bobo RH, Goffman T, Zhuang Z, Oldfied EH: Induction of glioblastoma multiforme in nonhuman primates after therapeutic doses of fractionated whole brain radiation therapy. J Neurosurg 97(6): 1378-1389, 2002.

Zabramski JM, Whiting D, Darouiche RO, Horner TG, Olson J, Robertson C, Hamilton AJ: Efficacy of antimicrobial-impregnated external ventricular drainage catheters: A prospective randomized, controlled trial. J Neurosurg. 98(4):725-730, 2003.

Bowers G, He J, Schultz K, Olavarria G, Maneval D, Olson JJ: Efficacy of adenoviral p53 delivery with SCH58500 in the intracranial 9L and RG2 models. Frontiers in Bioscience. 8:a54-61, May 1, 2003.

Olivi A, Grossman SA, Tatter S, Barker F, Judy K, Olson J, Bruce J, Hilt D, Fisher J, Piantadosi S: Dose escalation of Carmustine in surgical implanted polymers in patients with recurrent malignant glioma: A New Approaches to Brain Tumor Therapy CNS Consortium Trial. J Clinical Oncology 21(9): 1845-1849, 2003.

McConathy J, Martarello L, Malveaux EJ, Camp VM, Simpson NE, Simpson CP, Bowers GD, Zhang Z, Olson JJ, Goodman MM: Synthesis and evaluation of 2-amino-4-[(18)F]fluoro-2-methylbutanoic acid (FAMB): relationship of amino acid transport to tumor imaging properties of branched fluorinated amino acids. Nucl Med Biol 30(5): 477-490, 2003.

Hunter SB, Brat DJ, Olson JJ, von Deimling A, Zhou W, Ven Meir EG: Alterations in molecular pathways in diffusely infiltrating glial neoplasms: application to tumor classification and anti-tumor therapies. Int J Oncol. 23(4):857-869, 2003.

Tatter SB, Shaw EG, Rosenblum ML, Karvelis KC, Kleinberg L, Weingart J, Olson JJ, Crocker IR, Brem S, Pearlman JL, Fisher JD, Carson KA, Grossman SA: An inflatable balloon catheter and liquid 125I radiation source (Gliasite Radiation Therapy System) for treatment of recurrent glioma: multicenter and feasibility study. J Neurosurg 99:297-303, 2003.

Narayan P, Crocker I, Elder E, Olson JJ: Safety and efficacy of concurrent interstitial radiation and hyperthermia in the treatment of progressive malignant brain tumors. Oncology Reports. 11: 97-103, 2004.

Schinazi RF, Hurwitz SJ, Liberman I, Glazkova Y, Mourier NS, Olson J, Keane T: Tissue disposition of 5-o-carboranyluracil - A novel agent for boron neutron capture therapy of prostate cancer. Nucleosides, Nucleotides, and Nucleic Acids 23: 291-306, 2004.

Junge CE, Lee CJ, Hubbard KB, Zhang Z, Olson JJ, Hepler JR, Brat DJ, Traynelis ST: Protease-activated receptor-1 (PAR1) in human brain: localization and functional expression in astrocytes. Experimental Neurology 188: 94-103, 2004.

Olson JJ, James D, Lawson D, Hunter S, Tang G, Billingsley J: Correlation of the response of recurrent malignant gliomas treated with interferon with tumor interferon alpha gene content. Int J Oncol 25: 419-427, 2004.

Phuphanich S, Brat DJ, Olson JJ: Delivery systems and molecular targets of mechanism-based therapies for GBM. Review. Expert Rev Neurother 4(4):649-663, 2004.

Chiocca EA, Abbed KM, Tatter S, Louis DN, Hochberg FH, Barker F, Kracher J, Grossman SA, Fisher JD, Carson K, Rosenblum M, Mikkelsen T, Olson J, Markert J, Rosenfeld S, Nabors LB, Brem S, Phuphanich S, Freeman S, Kaplan R, Zwiebel J. Related Articles, Links A Phase I Open-Label, Dose-Escalation, Multi-Institutional Trial of Injection with an E1B-Attenuated Adenovirus, ONYX-015, into the Peritumoral Region of Recurrent Malignant Gliomas, in the Adjuvant Setting. Mol Ther 10(5):958-66, 2004.

Post DE, Devi NS, Li Z, Brat DJ, Kaur B, Nicholson A, Olson JJ, Zhang Z and Van Meir EG (2004) Cancer therapy with a replicating oncolytic adenovirus targeting the hypoxic microenvironment of tumors. Clin Cancer Res 10(24): 8603-8612, 2004.

Tan C, de Noronha RG, Roecker AJ, Pyrzynska B, Khwaja F, Zhang Z, Zhang H, Teng Q, Nicholson AC, Giannakakou P, Zhou W, Olson JJ, Pereira MM, Nicolaou KC, and Van Meir EG: Identification of a novel small molecule inhibitor of the hypoxia-inducible factor-1 (HIF-1) pathway. Cancer Res 65(2): 605-612, 2005.

Hunter SB, Varma V, Shehata B, Nolen JDL, Cohen C, Olson JJ, Ou CY: Apolipoprotein D expression in primary brain tumors: Analysis by quantitative RT-PCR in formalin-fixed, paraffin-embedded tissue. J Histochem Cytochem 53:963-969, 2005.

Khwaja FW, Nolen JD, Mendrinos SE, Lewis MM, Olson JJ, Pohl J, Van Meir EG, Ritchie JC, Brat DJ: Proteomic analysis of cerebrospinal fluid discriminates malignant and nonmalignant disease of the central nervous system and identifies specific protein markers. Proteomics 6:6277-87, 2006

Kang SH, Cho HT, Devi S, Zhang Z, Escuin D, Liang Z, Mao H, Brat DJ, Olson JJ, Simons JW, LaVallee TM, Giannakakou P, Van Meir EG, Shim H. Antitumor Effect of 2-Methoxyestradiol in a Rat Orthotopic Brain Tumor Model. Cancer Res 66: 11991-1997, 2006.

Chhabra VS, Zhang J, Olson JJ: Association between an arachnoid cyst and intracranial aneurysms misdiagnosed as a cystic tumor with a mural nodule. Neursurgical Focus 22: E3, 2007