Assistant Professor, Department of Neurosurgery Director of Functional and Stereotactic Neurosurgery Director, Laboratory for Neural Repair 1365B Clifton Rd., NE, Ste. 6200 Atlanta, GA 30322 Appt. Phone: 404-778-5770

• Areas of Clinical Interest
• Research Articles
• Manuscripts Submitted
• Publications
• Book Chapters
• Research
• Movement Disorders Center Website

Robert E. Gross earned an M.D. degree and a Ph.D. degree from Albert Einstein College of Medicine, Bronx, New York. Dr. Grossman completed his general surgery internship and neurosurgical residency at Albert Einstein College of Medicine and Montefiore Medical Center.

Upon completing his neurosurgical residency, he did a fellowship in functional and stereotactic neurosurgery at the University of Toronto and The Toronto Hospital in Toronto, Ontario, Canada. He completed a visiting fellowship in epilepsy surgery at Yale University and Yale/New Haven Hospital in New Haven, Connecticut. He is currently Assistant Professor in the Department of Neurosurgery at Emory University School of Medicine.

Dr. Gross has authored many scientific articles, abstract and chapters in medical textbooks and journals. He has been a visiting professor at major universities throughout the United States and Canada. During his career in medicine, he has won many awards.

His research interests focus on: restorative approaches (including cell and gene therapy) for Parkinson's disease and other neurodegenerative disorders; physiology of movement disorders (Parkinson's disease, tremor, dystonia); novel surgical techniques for epilepsy (e.g. deep brain stimulation, cell and gene therapy). In particular, he has been elucidating the role of axon guidance molecules in the development and reconstruction of the nigrostriatal pathway, which degenerates in P.D. This approach, which encompasses molecular and cellular engineering in combination with neurotransplantation, may be generally useful in reconstructive approaches for many types of nervous system degeneration and injury.

Dr. Gross has been active in organized neurosurgery, holding a variety of positions. He is currently an Advisory Board Member of the American Society for Stereotactic and Functional Neurosurgery.

In July of 2007, Dr. Gross, along with Steve M. Potter, Ph.D. of the Department of Biomedical Engineering at the Georgia Institute of Technology and Emory University, was the recipient of a prestigous grant from The Epilepsy Research Foundation (ERF) for translational research funding awards supporting innovative epilepsy products. The grant will support the development of a novel electrical stimulation approach that directly controls the activity of the brain to attain a more stable state from which seizures will not arise. You can read the press release for the research grant here.


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Areas of Clinical Interest: ablative procedures cell therapy deep brain stimulation dystonia epilepsy epilepsy surgery gene therapy neurodegenerative disorders Parkinson's disease physiology of movement disorders restorative approaches transplantation tremor

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Research Articles

Lu X, Gross RE, Bagchi S and Rubin CS: Cloning, structure and expression of the gene for a novel regulatory subunit of cAMP-dependent protein kinase in Caenorhabditis elegans. Journal of Biological Chemistry 265:3293-3303, 1990.

Gross RE, Bagchi S, Lu X and Rubin CS: Cloning, characterization and expression of the gene for the catalytic subunit of camp-dependent protein kinase in Caenorhabditis elegans. Identification of highly conserved and unique isoforms generated by alternative splicing. Journal of Biological Chemistry 265:6896-6907, 1990.

Gross RE, Lu X and Rubin CS: Regulation of the expression of the regulatory subunits of camp-dependent protein kinase IIbeta in Friend erythroleukemic cells. Evidence for post-transcriptional control and a central role for the catalytic subunit. Journal of Biological Chemistry 265:8152-8158, 1990.

Mehler MF, Marmur R, Gross RE, Mabie PC, Zang Z, Papavasiliou A, Kessler JA: Cytokines regulate the cellular phenotype of developing neural lineage species. International Journal of Developmental Neuroscience 13:214-240, 1995.

Gross RE, Mehler MF, Mabie PC, Zang Ziyang, Santchi L and Kessler JA: Bone morphogenetic proteins promote astroglial lineage commitment by mammalian subventricular zone progenitor cells. Neuron 17:595-606, 1996.

Michaelson MD, Mehler MF, Xu H, Gross RE and Kessler JA: Interleukin 7 is trophic for embryonic neurons and is expressed in developing brain. Developmental Biology 179:251-263, 1996.

Gross RE, Lozano AM, Lang AE, Tasker RR, Hutchison WD and Dostrovsky JO: The effects of GPi pallidotomy on Parkinson's Disease: Study design and assessment techniques. Acta Neurochir (suppl) 68:24-28, 1997.

Gross RE and Lozano AM: The surgical management of movement disorders. Contemporary Neurosurgery 19:1-9, 1997.

Lozano AM, Kumar R, Gross RE, Giladi N, Hutchison W, Dostrovsky JO and Lang AE: Globus pallidus internus pallidotomy for generalized dystonia. Movement Disorders 12:865-870, 1997.

Lombardi WJ, Andreason PJ, Sirocco KY, Gross RE, Rio DE, Umhau JC and Hommer DW: Metabolism in the dorsolateral fronto-subcortical circuit predicts perseveration on the Wisconsin Card Sorting Test following closed-head injury. Journal of Clinical and Experimental Neuropsychology 21:2-16, 1999.

Wennberg R, Gross D, Quesney F, Gross RE, Oliver A and Lozano AM: Transient epileptic foci secondary to subdural and epidural electrode placement. Clinical Neurophysiology 110:419-423, 1999.

Gross RE, Lombardi WJ, Hutchison WD, Narula S, Saint-Cyr J, Dostrovsky JO, Tasker RR, Lang AE and Lozano AM: Variability in lesion location following microelectrode-guided pallidotomy for Parkinson's Disease: Anatomic, physiologic and technical factors determining lesion distribution. Journal of Neurosurgery 90:468-477, 1999.

Gross RE, Lombardi WJ, Lang AE, Duff J, Hutchison WD, Saint-Cyr J, Tasker RR and Lozano AM: Relationship of lesion location to clinical outcome following microelectrode-guided pallidotomy for Parkinson's Disease. Brain 122:405-416, 1999.

Lang AE, Duff J, Saint-Cyr JA, Trepanier L, Gross RE, Lombardi WJ, Montgomery E, Hutchinson W, Lozano AM: Posteroventral medial pallidotomy in Parkinson's Disease. Journal of Neurology 246:S28-S41, 1999.

Gross RE, Dean A, Lewine J, Chong B, Jones G, Funke M, McDonald P: Relationship of magnetic source imaging to ictal electrocorticography in a neuronavigational workspace. Stereotactic and Functional Neurosurgery 73:109-114, 1999.

Lombardi WJ, Gross RE, Trepanier LL, Lang AE, Lozano AM and Saint-Cyr JA: Relationship of lesion location to cognitive outcome following microelectrode-guided pallidotomy for Parkinson's Disease: Support for the existence of cognitive circuits in the human pallidum. Brain 123:746-768, 2000.

Gross RE, Lozano AM: 22 Progress in neurostimulation for movement disorders. Neurological Research 247-258, 2000.

Lombardi WJ, Woolsten D, Roberts JW and Gross RE: Cognitive deficits in patients with essential tremor. Neurology, in press.

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Manuscripts Submitted

Lewine JD, Edgar JC, Weisend MP, Davis JT, Burr R, Campbell R, Cogburn M, Lombardi W, Skirboll S, Gross RE, MacDonald J, Baldwin NG, Heilbrun MP, Shih J, Dean A, Funke M, Mingquin H, Jones GM, Chong BW, Lee RR and Orrison WW: Magnetoencephalographic specification of cerebral dominance for language in neurologically normal subjects and neurosurgical patients with functional and/or structural lesions. Manuscript submitted for publication.

Gross RE, Lonser RR, Maynard E, Roberts JW, Lombardi WJ: Simultaneous bilateral pallidotomy for the treatment of bilateral ballism.

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Publications

Endoluminal Stent Placement and Coil Embolization for the Management of Carotid Artery Pseudoaneurysms Journal of Endovascular Therapy Pages: 8: 53-61

Endovascular Treatment of Intracranial Aneurysms with Guglielmi Detachable Coils: Emphasis on New Techniques Journal of Clinical Neuroscience Pages: 7: 244-253

Quality Improvement Guidelines for Adult Diagnostic Angiography AJNR Pages: 21: 146-150

Risk of Cerebral Angiography in Patients with Subarachnoid Hemorrhage, Cerebral Aneurysm, and Arteriovenous Malformation: A Meta-Analysis Stroke Pages: 30: 317-320

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Book Chapters

House P and Gross RE: Computer-assisted image-guided stereotaxis in movement disorder surgery. In: Schulder M. (ed) Handbook of Stereotactic and Functional Neurosurgery, Marcel Dekker, Inc., in press.